Response differences in monkey TE and perirhinal cortex: Stimulus association related to reward schedules
Response differences in monkey TE and perirhinal cortex: Stimulus association related to reward schedules
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DOI：
10.1152/jn.2000.83.3.1677
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发表时间：
2000-03-01
影响因子：
2.5
通讯作者：
Richmond, BJ
中科院分区：
文献类型：
--
作者：
Liu, Z;Richmond, BJ
猴子TE和嗅周皮层的反应差异：与奖励时间表相关的刺激关联。神经生理学杂志。83. 1677 - 1692年，2000年。解剖学和行为学证据表明，TE和嗅周皮质是两个直接相连但不同的下颞区。尽管这种差异，在这两个领域的神经元的生理特性通常是相似的，在这两个领域的神经元显示复杂的视觉模式的选择性，并显示在连续延迟匹配到样本（DMS）试验，注意力和刺激熟悉性的行为背景相关的反应调制。在这里，我们确定这两个领域的神经元活动的生理差异。我们记录了单个神经元从TE区和嗅周皮层，而猴子执行一个简单的行为任务，使用随机交错的视觉提示奖励时间表的一个，两个，或三个DMS试验。猴子们利用线索与奖励时间表的关系（由亮度表示）来调整他们的行为表现。在奖励即将到来的试验中，他们表现得最快，最准确，随着中间试验的增加，他们的表现逐渐下降。因此，随着试验进度的推进，猴子似乎更有动力。TE和嗅周皮质中的神经元都会对与奖励时间表相关的视觉线索和DMS试验中使用的刺激模式做出反应。正如预期的那样，两个区域的神经元对DMS模式表现出反应选择性，并且在DMS试验中与行为背景相关的调制显著但很小。然而，TE和嗅周神经元表现出显着不同的响应特性。嗅周反应的潜伏期分布集中在66 ms后，比TE反应的分布，一个更大的差异比10 - 15 ms通常发现在顺序连接的视觉皮层区域。在TE中，线索相关反应与线索的亮度有关。在嗅周皮层，线索相关的反应与独立的线索的亮度的审判时间表。例如，一些嗅周神经元在任何奖励计划（包括一次试验计划）的第一次试验中做出反应，而其他神经元在第一次试验中没有反应，但在任何计划的最后一次试验中做出反应。大多数嗅周神经元与时间表的关系较为复杂。TE神经元的线索相关活动被最吝啬地解释为对刺激亮度的响应，而嗅周神经元的线索相关活动被最吝啬地解释为携带关于动物通过奖励时间表的进展的关联信息。嗅周皮层可能是衡量工作时间表和奖励之间关系的系统的一部分。
Response differences in monkey TE and perirhinal cortex: stimulus association related to reward schedules. J. Neurophysiol. 83. 1677-1692, 2000. Anatomic and behavioral evidence shows that TE and perirhinal cortices are two directly connected but distinct inferior temporal areas. Despite this distinctness, physiological properties of neurons in these two areas generally have been similar with neurons in both areas showing selectivity for complex visual patterns and showing response modulations related to behavioral context in the sequential delayed match to-sample (DMS) trials, attention, and stimulus familiarity. Here we identify physiological differences in the neuronal activity of these two areas. We recorded single neurons from area TE and perirhinal cortex while the monkeys performed a simple behavioral task using randomly interleaved visually cued reward schedules of one, two, or three DMS trials. The monkeys used the cue's relation to the reward schedule (indicated by the brightness) to adjust their behavioral performance. They performed most quickly and most accurately in trials in which reward was immediately forthcoming and progressively less well as more intermediate trials remained. Thus the monkeys appeared more motivated as they progressed through the trial schedule. Neurons in both TE and perirhinal cortex responded to both the visual cues related to the reward schedules and the stimulus patterns used in the DMS trials. As expected, neurons in both areas showed response selectivity to the DMS patterns, and significant, but small, modulations related to the behavioral context in the DMS trial. However, TE and perirhinal neurons showed strikingly different response properties. The latency distribution of perirhinal responses was centered 66 ms later than the distribution of TE responses, a larger difference than the 10-15 ms usually found in sequentially connected visual cortical areas. In TE, cue-related responses were related to the cue's brightness. In perirhinal cortex, cue-related responses were related to the trial schedules independently of the cue's brightness. For example, some perirhinal neurons responded in the first trial of any reward schedule including the one trial schedule, whereas other neurons failed to respond in the first trial but respond in the last trial of any schedule. The majority of perirhinal neurons had more complicated relations to the schedule. The cue-related activity of TE neurons is interpreted most parsimoniously as a response to the stimulus brightness, whereas the cue-related activity of perirhinal neurons is interpreted most parsimoniously as carrying associative information about the animal's progress through the reward schedule. Perirhinal cortex may be part of a system gauging the relation between work schedules and rewards.