High Consistency of Regional Cortical Thinning in Aging across Multiple Samples
High Consistency of Regional Cortical Thinning in Aging across Multiple Samples
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DOI：
10.1093/cercor/bhn232
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发表时间：
2009-09-01
期刊：
影响因子：
3.7
通讯作者：
Walhovd, Kristine B.
中科院分区：
文献类型：
--
作者：
Fjell, Anders M.;Westlye, Lars T.;Walhovd, Kristine B.
皮质厚度和体积的横截面磁共振成像（MRI）研究显示，年龄对大面积的影响，但在影响的定位和幅度方面，研究之间存在很大差异。这些差异阻碍了对衰老对脑形态计量学影响的理解，并限制了MR在健康和病理性年龄相关脑变化研究中的潜在用途。本研究通过评估年龄对6个不同样本共883名参与者皮质厚度影响的一致性来克服这个问题。使用基于表面的分割程序（FreeSurfer）连续计算大脑表面的皮质厚度。结果表明，在上级，中间，和额下回，上级和颞中回，楔前叶，下部和上级顶叶皮质，梭状回和舌回，以及颞顶叶交界处的样本一致的年龄效应。最强的影响出现在额上上级回和额下回，以及颞叶的上级部分。下颞叶和前扣带皮层受年龄影响相对较小。结果进行了讨论有关认知老化的领先理论。
Cross-sectional magnetic resonance imaging (MRI) studies of cortical thickness and volume have shown age effects on large areas, but there are substantial discrepancies across studies regarding the localization and magnitude of effects. These discrepancies hinder understanding of effects of aging on brain morphometry, and limit the potential usefulness of MR in research on healthy and pathological age-related brain changes. The present study was undertaken to overcome this problem by assessing the consistency of age effects on cortical thickness across 6 different samples with a total of 883 participants. A surface-based segmentation procedure (FreeSurfer) was used to calculate cortical thickness continuously across the brain surface. The results showed consistent age effects across samples in the superior, middle, and inferior frontal gyri, superior and middle temporal gyri, precuneus, inferior and superior parietal cortices, fusiform and lingual gyri, and the temporo-parietal junction. The strongest effects were seen in the superior and inferior frontal gyri, as well as superior parts of the temporal lobe. The inferior temporal lobe and anterior cingulate cortices were relatively less affected by age. The results are discussed in relation to leading theories of cognitive aging.