The beneficial transfusion effect on kidney graft survival attributed to clonal deletion.
The beneficial transfusion effect on kidney graft survival attributed to clonal deletion.
复制标题
克隆删除对肾移植物存活的有益输血作用。
DOI：
10.1097/00007890-198402000-00001
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发表时间：
1984
期刊：
影响因子：
6.2
通讯作者：
Terasaki,PI
中科院分区：
文献类型：
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作者：
Terasaki,PI
一开始，Medawar发现输血使接受者对随后的移植免疫（1）。这种观点几乎被普遍接受了25年，但是，在1973年，与移植的基本原则相反的发现出现在临床肾移植的背景下。输血后，移植存活率并没有降低，相反，令人费解的是，存活率增加了（2）。虽然大量的研究已经证实了这一现象本身（3，4），对这一令人困惑的矛盾的解释一直困扰着我们。10年后的今天，我们提出了一个新的理论，希望它能统一关于输血的积累知识，该假说指出，输血的主要功能确实是使患者免疫，而不是诱导耐受，或诱导增强，或作为供体选择机制（3）。正如从一开始就预期的那样，输血免疫，但免疫抑制消除了响应克隆。
In the beginning, Medawar discovered that blood transfusions immunized recipients against subsequent transplants (1). This view was almost universally held for 25 years–but, in 1973, findings contrary to this fundamental tenet of transplantation emerged in the setting of clinical kidney transplants. Following transfusions, transplant survival rates were not diminished–instead, inexplicably, survival rates were augmented (2). Though a multitude of studies have confirmed the phenomenon itself (3, 4), an explanation for this perplexing contradiction has eluded us. Now, 10 years later, we advance a new theory which we hope will unify the accumulated knowledge about transfusions.The hypothesis states that the primary function of transfusions is, indeed, to immunize patients and not to induce toler-ance, or to induce enhancement, or to serve as a donor selection mechanism (3). As expected from the beginning, transfusions immunize but immunosuppression eliminates the responding clones.