The association of lipoprotein lipase PvuII polymorphism and niacin intake in the prevalence of metabolic syndrome: a KMSRI-Seoul study
The association of lipoprotein lipase PvuII polymorphism and niacin intake in the prevalence of metabolic syndrome: a KMSRI-Seoul study
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DOI：
10.1007/s12263-011-0251-9
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发表时间：
2012-04-01
影响因子：
3.5
通讯作者：
Lee, Myoungsook
中科院分区：
文献类型：
--
作者：
Shin, Eunjung;Park, Na-Young;Lee, Myoungsook
与 LPL 活性相关的脂蛋白脂肪酶 (LPL) 多态性与血浆脂质和脂蛋白水平相关。我们的目的是调查 LPL PvuII 多态性的频率以及 LPL PvuII 多态性和烟酸摄入量对韩国人代谢综合征 (MetSyn) 患病率的影响。完成了生活方式问卷、人体测量和饮食记录，并测定了 548 名韩国人的 LPL PvuII 多态性、LPL 质量和血脂谱（MetSyn：278，非 MetSyn：270）。与非 MetSyn 组相比，MetSyn 组显示 P1P1（野生型）频率显着降低，P1P2（异型）频率显着升高。与P1P1组相比，P2P2（突变型）组显着表现出较低水平的HDLc和LPL质量以及较高水平的TG。随着烟酸摄入量的增加，P2P2 组的 LPL 质量下降 (r (2) = 0.07)。特别是，烟酸摄入量最低的组（千分之14.82毫克/天）与P2P2突变组中的其他组相比，MetSyn的风险更高，增加了3倍多。然而，与 P1 等位基因组相比，P2P2 组在最佳烟酸摄入水平（14.83-17.80 毫克/天）时，MetSyn 风险下降了 74%。研究结果表明，最佳烟酸摄入水平可有效降低 P2P2 突变组中韩国 MetSyn 的患病率。
Lipoprotein lipase (LPL) polymorphism correlated with LPL activity is associated with plasma lipid and lipoprotein levels. We aimed to investigate the frequency of LPL PvuII polymorphism and effects of LPL PvuII polymorphism and niacin intake on the prevalence of metabolic syndrome (MetSyn) in Koreans. Lifestyle questionnaires, anthropometry, and dietary records were completed, and LPL PvuII polymorphism, LPL mass, and lipid profiles were determined in 548 Koreans (MetSyn: 278, Non-MetSyn: 270). The MetSyn group showed a significantly lower frequency of P1P1 (wild type) and a higher frequency of P1P2 (hetero type) than the non-MetSyn group. The P2P2 (mutant type) group significantly showed lower levels of HDLc and LPL mass and a higher level of TG than the P1P1 group. As niacin intake increased, LPL mass decreased in the P2P2 group (r (2) = 0.07). In particular, the lowest niacin intake group (a parts per thousand currency sign14.82 mg/day) increased more than 3 times with regard to a higher risk of MetSyn than the others in the P2P2 mutant groups. However, the MetSyn risk declined 74% at the optimal levels of niacin intake (14.83-17.80 mg/day) in the P2P2 group compared to those of the P1 allele group. The findings indicate that optimal levels of niacin intake effectively decreased Korean MetSyn prevalence in the P2P2 mutant group.