Pancreatic islets microencapsulation with polylactide-co-glycolide
Pancreatic islets microencapsulation with polylactide-co-glycolide
复制标题
DOI：
10.1016/s0041-1345(01)01918-2
复制
发表时间：
2001-02-01
影响因子：
0.9
通讯作者：
Nacucchio, M
中科院分区：
文献类型：
--
作者：
Abalovich, A;Jatimliansky, C;Nacucchio, M
THE SUCCESSFUL treatment of type I diabetes relies on the development of an accurate glucose sensor. To date, the most efficient glucose sensor is the pancreatic ß-cell. Therefore, the development of a suitable method for pancreatic islets transplantation is an important aim in the search for a cure for this disease. Several different bioartificial pancreas (BAP) devices have been used; 1 however, microencapsulated islets (MI) have additional advantages that make them a good candidate for the treatment of diabetes. Several materials have been used to microencapsulate islets. In this work, we evaluated the efficiency of polylactic-co-glycolide (PLGA) microcapsules as a BAP, and we compared its insulin yields with that of islets placed in diffusion chambers (DC) filled with agarose. We also evaluated the performance of MI on rats with streptozotocin-induced diabetes.
