Pulmonary Mycobacterium bovis BCG Vaccination Confers Dose-Dependent Superior Protection Compared to That of Subcutaneous Vaccination
Pulmonary Mycobacterium bovis BCG Vaccination Confers Dose-Dependent Superior Protection Compared to That of Subcutaneous Vaccination
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DOI：
10.1128/cvi.00700-13
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发表时间：
2014-04-01
影响因子：
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通讯作者：
Martin, Carlos
中科院分区：
文献类型：
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作者：
Aguilo, Nacho;Toledo, Ana Maria;Martin, Carlos
在世界范围内，牛分枝杆菌BCG疫苗是最广泛使用的疫苗之一。然而，它似乎对预防肺结核无效。在这里，我们表明，肺卡介苗疫苗接种的小鼠与广泛的剂量范围提供了上级保护结核分枝杆菌的挑战相比，皮下接种。
Worldwide, the Mycobacterium bovis BCG vaccine is one of the most widely used vaccines. However, it appears to be ineffective in preventing pulmonary tuberculosis. Here, we show that pulmonary BCG vaccination of mice with a broad dose range provides superior protection against Mycobacterium tuberculosis challenge compared to that of subcutaneous vaccination.