5-Lipoxygenase: mechanisms of regulation
5-Lipoxygenase: mechanisms of regulation
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DOI：
10.1194/jlr.r800062-jlr200
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发表时间：
2009-04-01
影响因子：
6.5
通讯作者：
Samuelsson, Bengt
中科院分区：
文献类型：
--
作者：
Radmark, Olof;Samuelsson, Bengt
5-脂氧合酶（5-LO）催化白三烯（LTs）生物合成的两个步骤，白三烯是一组由花生四烯酸（AA）衍生的炎症脂质介质。LT拮抗剂用于治疗哮喘；最近，它在动脉粥样硬化中的潜在作用引起了人们极大的兴趣。此外，5-LO代谢物在肿瘤发生中的可能作用已经出现。jlr因此，了解这种脂氧合酶的生物化学对治疗各种疾病具有潜在的意义。-Radmark， O.和B. Samuelsson. 5-脂氧合酶：调节机制。[j] .油脂杂志。2009。S40-S45。
5-Lipoxygenase (5-LO) catalyzes two steps in biosynthesis of leukotrienes (LTs), a group of lipid mediators of inflammation derived from arachidonic acid (AA). LT antagonists are used in treatment of asthma; more recently a potential role also in atherosclerosis has raised considerable interest. Furthermore, possible effects of 5-LO metabolites in relation to tumorigenesis have emerged.jlr Thus, an understanding of the biochemistry of this lipoxygenase has potential implications for treatment of various diseases.-Radmark, O., and B. Samuelsson. 5-Lipoxygenase: mechanisms of regulation. J. Lipid Res. 2009. S40-S45.