Risk of subsequent cancer following invasive or in situ squamous cell skin cancer
Risk of subsequent cancer following invasive or in situ squamous cell skin cancer
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DOI：
10.1016/s1047-2797(01)00276-9
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发表时间：
2002-10-01
影响因子：
5.6
通讯作者：
Nelson, LM
中科院分区：
文献类型：
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作者：
Efird, JT;Friedman, GD;Nelson, LM
目得：确定随后的癌症的风险鳞状细胞皮肤cancer.METHODS：使用计算机化的手术病理记录和会员数据从健康维护组织，我们回顾性地确定了822个人与原发性鳞状细胞皮肤癌（SCSC）和3662比较科目匹配的年龄，性别，种族，居住区，和长度的会员资格。如果患者没有癌症既往史，并接受至少一次多阶段健康检查和WHO问卷调查，则将其纳入研究。患者随后的浸润性癌症随访长达24年，平均随访时间为7.8年。SCSC患者-总体上有明显更大的风险[经体重指数（BMI）和教育调整]发生后续癌症（不包括非黑色素瘤皮肤癌）[风险比（RR）= 1.4，95%置信区间（CI）= 1.2-1.6]，基底细胞皮肤癌（RR = 13.8，95%CI = 8.8-21.9），消化道癌（RR = 1.6，95%CI = 1.1-2-4）和泌尿生殖道癌（RR = 1.5，95%CI = 1.0-2.0）。调整后风险增加，但无统计学显著性（RR大于或等于1.4）也观察到唇癌、口腔癌和咽癌（RR = 3.9，95% CI = 0.6-25.0）;非皮肤鳞状细胞癌（RR = 1.9，95%CI = 0.9-4-4）;呼吸道和胸内癌（RR = 1.4，95%CI = 0.8-2.6）。此外，酒精消费，结合职业暴露，婚姻状况，吸烟史的多变量模型没有实质性改变任何显着的积极协会与SCSCSC.CONCLUSIONS：我们的研究结果表明，诊断为SCSC患者可能会在随后的癌症在许多网站的风险增加，虽然几个估计的风险估计的机会范围内没有真正的关联。(C)2002年爱思唯尔科技有限公司All rights reserved.
PURPOSE: Determine the risk of subsequent cancer following squamous cell skin cancer.METHODS: Using computerized surgical pathology records and membership data from a health maintenance organization, we retrospectively identified 822 individuals with primary squamous cell skin cancer (SCSC) and 3662 comparison subjects matched for age, sex, race, residence area, and length of member-ship. Patients were included in the study if they had no prior history of cancer, and received at least one multiphasic health checkup and questionnaire WHO. Patients were followed for subsequent invasive cancer up to 24 years, with a mean follow-up time of 7.8 years.RESULTS: SCSC patients-had a significantly greater risk [adjusted for body mass index (BMI) and education] for subsequent cancer overall (excluding non-melanoma skin cancer) [risk ratio (RR) = 1.4, 95% confidence interval (CI) = 1.2-1.6], and for basal cell skin cancer (RR = 13.8, 95% CI = 8.8-21.9), digestive (RR = 1.6, 95% CI = 1.1-2-4), and genitourinary cancers (RR = 1.5, 95% CI = 1.0-2.0). An increased, but not statistically significant, adjusted risk (RR greater than or equal to 1.4) was also observed for lip, oral cavity, and pharynx cancer (RR = 3.9, 95% CI = 0.6-25.0); non-cutaneous squamous call cancer (RR = 1.9, 95% CI = 0.9-4-4); and respiratory and intrathoracic cancer (RR = 1.4, 95% CI = 0.8-2.6). The addition of alcohol consumption, combined occupational exposure, marital status, and smoking history to the multivariate model did not materially change any significant positive associations with SCSC.CONCLUSIONS: Our results suggest that patients diagnosed with SCSC may be at an increased risk of subsequent cancer at many sites, although several estimated risk estimates were within the limits of chance given no true association. (C) 2002 Elsevier Science Inc. All rights reserved.