¹⁸F-FDG PET metabolic parameters and MRI perfusion and diffusion parameters in hepatocellular carcinoma: a preliminary study.
¹⁸F-FDG PET metabolic parameters and MRI perfusion and diffusion parameters in hepatocellular carcinoma: a preliminary study.
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DOI：
10.1371/journal.pone.0071571
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Kim MJ
中科院分区：
文献类型：
--
作者：
Ahn SJ;Park MS;Kim KA;Park JY;Kim I;Kang WJ;Lee SK;Kim MJ
在同一肿瘤中，葡萄糖代谢、血流灌注和水分扩散可能是相互关联或相互影响的。了解它们之间的关系可以扩大对肿瘤特征的认识，为肿瘤影像领域做出贡献。本研究的目的是利用18F-FDG正电子发射断层扫描(PET)、动态增强磁共振成像(DCE-MRI)和弥散加权成像(DWI)等多种成像技术，评价晚期肝细胞癌(HCC)代谢、血管和细胞形态之间的关系。21例晚期肝癌患者在治疗前接受了18F-FDGPET、DCE-MRI和DWI检查。获得肿瘤18F-FDG-PET的最大标准摄取值(SUVmax)、DCE-MRI的体积传递常数(KTRANS)和DWI的表观扩散系数(ADC)的变量，并用Spearman相关分析检验它们之间的关系。采用Mann-Whitney检验评价门静脉血栓形成对最大血流速度(SUVmax)、最大血流速度(KTrans)和最大血流速度(ADC)的影响。Svmax与Ktrans max呈显著负相关(ρ = −0.622，p = 0.002)。但ADC与KTRANS或SUVmax之间无相关性(p>；0.05)。门静脉血栓形成与否并不影响SUV最大值以及ADC和KTRANS的变量(p>；0.05)。在这项研究中，在晚期肝癌中，SUV与KTRANS相关；肿瘤的葡萄糖代谢越高，其血流灌注就越低，这可能有助于指导靶向治疗。
Glucose metabolism, perfusion, and water diffusion may have a relationship or affect each other in the same tumor. The understanding of their relationship could expand the knowledge of tumor characteristics and contribute to the field of oncologic imaging. The purpose of this study was to evaluate the relationships between metabolism, vasculature and cellularity of advanced hepatocellular carcinoma (HCC), using multimodality imaging such as 18F-FDG positron emission tomography (PET), dynamic contrast enhanced (DCE)-MRI, and diffusion weighted imaging(DWI). Twenty-one patients with advanced HCC underwent 18F-FDG PET, DCE-MRI, and DWI before treatment. Maximum standard uptake values (SUVmax) from 18F-FDG-PET, variables of the volume transfer constant (Ktrans) from DCE-MRI and apparent diffusion coefficient (ADC) from DWI were obtained for the tumor and their relationships were examined by Spearman’s correlation analysis. The influence of portal vein thrombosis on SUVmax and variables of Ktrans and ADC was evaluated by Mann-Whitney test. SUVmax showed significant negative correlation with Ktrans max (ρ = −0.622, p = 0.002). However, variables of ADC showed no relationship with variables of Ktrans or SUVmax (p>0.05). Whether portal vein thrombosis was present or not did not influence the SUV max and variables of ADC and Ktrans (p>0.05). In this study, SUV was shown to be correlated with Ktrans in advanced HCCs; the higher the glucose metabolism a tumor had, the lower the perfusion it had, which might help in guiding target therapy.
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