Accumulation of bioactive lipids during storage of blood products is not cell but plasma derived and temperature dependent
Accumulation of bioactive lipids during storage of blood products is not cell but plasma derived and temperature dependent
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DOI：
10.1111/j.1537-2995.2011.03177.x
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发表时间：
2011-11
期刊：
影响因子：
2.9
通讯作者：
A. Vlaar;W. Kulik;R. Nieuwland;C. Peters;A. Tool;R. van Bruggen;N. Juffermans;D. de Korte
中科院分区：
文献类型：
--
作者：
A. Vlaar;W. Kulik;R. Nieuwland;C. Peters;A. Tool;R. van Bruggen;N. Juffermans;D. de Korte
背景技术背景：认为在含细胞血液制品储存期间蓄积的生物活性脂质（溶血磷脂酰胆碱[lysoPC]）是通过激活中性粒细胞导致输血相关急性肺损伤发作的原因。LysoPCs被认为是来源于细胞膜降解产物，例如通过部分水解PC的磷脂酰胆碱（PC），这是一个由磷脂酶A2（PLA2）催化的过程。
BACKGROUND: Bioactive lipids (lysophosphatidylcholines [lysoPCs]) accumulating during storage of cell‐containing blood products are thought to be causative in onset of transfusion‐related acute lung injury through activation of neutrophils. LysoPCs are thought to be derived from cell membrane degradation products such as phosphatidylcholines (PC) by partial hydrolysis of PC, a process that is catalyzed by phospholipase A2 (PLA2).