Clinical physiology of adrenergic receptor regulation.
Clinical physiology of adrenergic receptor regulation.
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肾上腺素能受体调节的临床生理学。
DOI：
10.1152/ajpendo.1982.243.1.e43
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Lefkowitz,RJ
中科院分区：
文献类型：
--
作者：
Lefkowitz,RJ
放射配体结合研究现在允许直接调查α和β肾上腺素能受体。细胞膜中受体的浓度受到多种生理和病理生理变量的调节，在不同的条件下可能增加或减少。配体结合技术也揭示了肾上腺素能受体与激素敏感腺苷酸环化酶系统的其他组分耦合的方式。这种“耦合”也是一个高度调控的步骤，其控制对儿茶酚胺和组织的敏感性有重要影响。
Radioligand binding studies now permit the direct investigation of the alpha- and beta-adrenergic receptors. The concentration of the receptors in cell membranes is modulated by a wide variety of physiological and pathophysiological variables and may be either increased or decreased in different conditions. Ligand binding techniques have also shed light on the ways in which the adrenergic receptors are coupled to other components of the hormone-sensitive adenylate cyclase system. This “coupling” is also a highly regulated step, control of which importantly influences catecholamine and sensitivity of tissues.