Histone target selection within chromatin: an exemplary case of teamwork.
Histone target selection within chromatin: an exemplary case of teamwork.
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DOI：
10.1101/gad.236331.113
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发表时间：
2014-05-15
影响因子：
10.5
通讯作者：
Côté J
中科院分区：
文献类型：
--
作者：
Lalonde ME;Cheng X;Côté J
Histone modifiers like acetyltransferases, methyltransferases, and demethylases perform very precise post-translational modifications on specific histone residues, which in turn are recognized by different effector modules/proteins. In this review, Lalonde et al. cover the current understanding of how histone modifiers select their histone targets. Histone modifiers like acetyltransferases, methyltransferases, and demethylases are critical regulators of most DNA-based nuclear processes, de facto controlling cell cycle progression and cell fate. These enzymes perform very precise post-translational modifications on specific histone residues, which in turn are recognized by different effector modules/proteins. We now have a better understanding of how these enzymes exhibit such specificity. As they often reside in multisubunit complexes, they use associated factors to target their substrates within chromatin structure and select specific histone mark-bearing nucleosomes. In this review, we cover the current understanding of how histone modifiers select their histone targets. We also explain how different experimental approaches can lead to conflicting results about the histone specificity and function of these enzymes.
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影响因子：
2.9
作者：
Champagne KS;Saksouk N;Peña PV;Johnson K;Ullah M;Yang XJ;Côté J;Kutateladze TG
通讯作者：
Kutateladze TG
影响因子：
4.8
作者：
Altaf, Mohammed;Auger, Andreanne;Cote, Jacques
通讯作者：
Cote, Jacques
影响因子：
16
作者：
Altaf, Mohammed;Utley, Rhea T.;Cote, Jacques
通讯作者：
Cote, Jacques
DOI：
10.1126/science.1191078
发表时间：
2010-10-29
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bonasio R;Tu S;Reinberg D
通讯作者：
Reinberg D
DOI：
10.1073/pnas.1310156110
发表时间：
2013-07-09
影响因子：
11.1
作者：
Ali, Muzaffar;Rincon-Arano, Hector;Kutateladze, Tatiana G.
通讯作者：
Kutateladze, Tatiana G.