A network of topographic numerosity maps in human association cortex
A network of topographic numerosity maps in human association cortex
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DOI：
10.1038/s41562-016-0036
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发表时间：
2017-02-01
影响因子：
29.9
通讯作者：
Dumoulin, Serge O.
中科院分区：
文献类型：
--
作者：
Harvey, Ben M.;Dumoulin, Serge O.
感觉皮质和运动皮质各自包含多个地形图，其中感觉器官（例如视网膜或耳蜗）的结构映射到皮质表面上。这些感觉地图是分层组织的。例如，视野图包含的神经元代表越来越大的视觉空间部分，并具有越来越复杂的反应（1）。一些视觉神经元对刺激的反应具有特定的数字性，即一组物体的数量。我们最近发现了一个顶叶地形数字图，其中神经数字偏好在皮层表面逐渐发展（2），类似于感觉地图。根据这个类比，我们假设可能有多个数字度图。数字感知涉及许多认知功能，包括觅食（3），多目标跟踪（4），分散注意力（5），决策（6）和数学（7-9）。在这里，我们使用超高场（7特斯拉，7 T）功能性磁共振成像（fMRI）和神经模型为基础的分析，揭示数量选择性神经种群组织成六个广泛分离的地形图在每个半球。虽然我们描述了这些地图之间的细微差异，但它们的属性非常相似，不像感官地图的层次结构。这些地图被发现在涉及物体识别，运动感知，注意力控制，决策和数学的领域。多个数字地图可能允许与这些认知系统的相互作用，这表明数量处理在支持许多感知和认知功能中的广泛作用。
Sensory and motor cortices each contain multiple topographic maps with the structure of sensory organs (such as the retina or cochlea) mapped onto the cortical surface. These sensory maps are hierarchically organized. For example, visual field maps contain neurons that represent increasingly large parts of visual space with increasingly complex responses(1). Some visual neurons respond to stimuli with a particular numerosity the number of objects in a set. We recently discovered a parietal topographic numerosity map in which neural numerosity preferences progress gradually across the cortical surface(2), analogous to sensory maps. Following this analogy, we hypothesized that there may be multiple numerosity maps. Numerosity perception is implicated in many cognitive functions, including foraging(3), multiple object tracking(4), dividing attention(5), decision-making(6) and mathematics(7-9). Here we use ultra-high-field (7 Tesla, 7T) functional magnetic resonance imaging (fMRI) and neural-model-based analyses to reveal numerosity-selective neural populations organized into six widely separated topographic maps in each hemisphere. Although we describe subtle differences between these maps, their properties are very similar, unlike in sensory map hierarchies. These maps are found in areas implicated in object recognition, motion perception, attention control, decision-making and mathematics. Multiple numerosity maps may allow interactions with these cognitive systems, suggesting a broad role for quantity processing in supporting many perceptual and cognitive functions.