Relevance of major histocompatibility complex class II expression as a hallmark for the cellular differentiation in the human adrenal cortex.
Relevance of major histocompatibility complex class II expression as a hallmark for the cellular differentiation in the human adrenal cortex.
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主要组织相容性复合体 II 类表达作为人肾上腺皮质细胞分化标志的相关性。
DOI：
10.1210/jcem.82.9.4194
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
W. Scherbaum
中科院分区：
文献类型：
--
作者：
C. Marx;S. Bornstein;Gernot W. Wolkersdörfer;Michael Peter;W. G. Sippell;W. Scherbaum
Major histocompatibility complex (MHC) class II antigens are expressed on adrenocortical cells of the zona reticularis and have been shown to be a marker of dignity. This suggests a correlation to the zellular differentiation of the adrenal cortex. Therefore, we immunohistochemically investigated the MHC class II expression in the context of the ontogenesis of the zonal and cellular differentiation in fetal, postnatal, childhood, and adult adrenals. Cell types and cell turnover were studied using specific immune markers (including expression of CD95/ Fas), in situ end labeling of apoptosis, and electron microscopy. We show that prenatal (fetal and definitive) steroid cells, as well as postnatal adrenals, reveal no expression of MHC class II. In childhood, these antigens first appear by the fourth year, in parallel with the differentiation of reticularis cells. The expression index in childhood was 7.43% +/- 2.78 (mean +/- SEM), in adult adrenals 18.63% +/- 3.14 (third decade), and 15.15% +/- 1.26 (fourth through sixth decade). In conclusion, MHC class II expression and the development of the functional maturation of the adult adrenal cortex occur simultaneously. The expression of MHC class II on steroid cells may thus be involved in potential immune-adrenal interactions.
网状带的肾上腺皮质细胞通常表达 HLA-DR 抗原决定簇。
DOI：
--
发表时间：
1987
期刊：
The American journal of pathology
影响因子：
--
作者：
Khoury,EL;Greenspan,JS;Greenspan,FS
通讯作者：
Greenspan,FS