Actual medication pill burden and dosing frequency in HIV-infected patients with undetectable viral loads.
Actual medication pill burden and dosing frequency in HIV-infected patients with undetectable viral loads.
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DOI：
10.1177/154510970400300203
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发表时间：
2004-04-01
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影响因子：
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通讯作者：
Clay, Patrick G
中科院分区：
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作者：
Clay, Patrick G
研究表明，每日一次抗逆转录病毒（ARV）治疗方案的效果相当或更好，但由于没有考虑到伴随用药，未能量化艾滋病毒感染患者的真实每日给药频率和药丸负担。这项研究的目的是描述所有口服药物的每日总剂量（药片负担）和给药频率，而不仅仅是病毒载量检测不到的艾滋病毒感染者的抗逆转录病毒药物。对艾滋病毒初级保健诊所中无法检测到病毒载量的患者进行回顾性图表审查，确定了所有处方药的给药频率和药丸负担。这些患者被分为联合用药组（with）和仅服用抗逆转录病毒药物组（WITHOUT）。117名患者符合评估条件。有伴组93例，无伴组24例。WITH患者年龄较大（p< 0.05），美国疾病控制与预防中心（CDC）定义的HIV疾病晚期（p< 0.05）， HIV感染持续时间较长（p= 0.03），艾滋病持续时间较长（p= 0.02）。WITH患者的总药物负担显著增加(p
Studies have shown equivalent or improved outcomes with once-daily antiretroviral (ARV) regimens, but have failed to quantify the true daily dosing frequency and pill burden of HIV-infected patients, by not considering concomitant medications. This study was conducted to describe the total daily number (pill burden) and dosing frequency for all oral medicines, and not just ARV medications in HIV-infected patients with undetectable viral loads. A retrospective chart review of patients with undetectable viral loads in an HIV primary care clinic identified dosing frequency and pill burden for all prescribed medications. These patients were divided into those with concomitant medications (WITH) and those only on ARV medications (WITHOUT). One hundred and seventeen patients qualified for the evaluation. Ninety-three were in the WITH group and 24 were in the WITHOUT group. WITH patients were older (p < 0.05), and had advanced US Centers for Disease Control and Prevention (CDC)-defined HIV disease stage (p< 0.05), a longer duration of HIV infection (p= 0.03), and a longer duration of AIDS (p= 0.02). WITH patients had a significantly greater total pill burden (p