Pattern of dopamine signaling during aversive events predicts active avoidance learning.
Pattern of dopamine signaling during aversive events predicts active avoidance learning.
复制标题
厌恶事件期间的多巴胺信号传导模式预测主动回避学习。
DOI：
10.1073/pnas.1904249116
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发表时间：
2019
影响因子：
11.1
通讯作者：
Wanat,MatthewJ
中科院分区：
文献类型：
--
作者：
Stelly,ClaireE;Haug,GrahamC;Fonzi,KaitlynM;Garcia,MiriamA;Tritley,SeanC;Magnon,AlexaP;Ramos,MariaAliciaP;Wanat,MatthewJ
Learning to avoid aversive outcomes is an adaptive strategy to limit one’s future exposure to stressful events. However, there is considerable variance in active avoidance learning across a population. The mesolimbic dopamine system contributes to behaviors elicited by aversive stimuli, although it is unclear if the heterogeneity in active avoidance learning is explained by differences in dopamine transmission. Furthermore, it is not known how dopamine signals evolve throughout active avoidance learning. To address these questions, we performed voltammetry recordings of dopamine release in the ventral medial striatum throughout training on inescapable footshock and signaled active avoidance tasks. This approach revealed differences in the pattern of dopamine signaling during the aversive cue and the safety period that corresponded to subsequent task performance. Dopamine transmission throughout the footshock bout did not predict performance but rather was modulated by the prior stress exposure. Additionally, we demonstrate that dopamine encodes a safety prediction error signal, which illustrates that ventral medial striatal dopamine release conveys a learning signal during both appetitive and aversive conditions.
