The potential effects of changing HIV treatment policy on tuberculosis outcomes in South Africa: results from three tuberculosis-HIV transmission models
The potential effects of changing HIV treatment policy on tuberculosis outcomes in South Africa: results from three tuberculosis-HIV transmission models
复制标题
DOI：
10.1097/qad.0000000000000085
复制
发表时间：
2014-01-01
期刊：
影响因子：
3.8
通讯作者：
Dodd, Peter J.
中科院分区：
文献类型：
--
作者：
Pretorius, Carel;Menzies, Nicolas A.;Dodd, Peter J.
目标：许多国家正在考虑扩大艾滋病毒治疗，因为最近的研究结果强调了抗逆转录病毒疗法（ART）在减少艾滋病毒传播方面的作用，以及已经确定的生存益处。鉴于结核病和艾滋病毒流行之间的密切相互作用，扩大抗逆转录病毒治疗可能对结核病负担产生重要影响。以往的研究表明，抗逆转录病毒治疗扩大后可能对结核病产生广泛影响。我们使用了三个独立开发的结核病-艾滋病毒模型来估计在南非扩大抗逆转录病毒治疗对结核病的影响。设计：我们考虑了ART扩展的两个方面——改善ART前和ART服务的覆盖率，以及扩大基于CD4的ART资格标准（从CD4开始）
Objective(s):Many countries are considering expanding HIV treatment following recent findings emphasizing the effects of antiretroviral therapy (ART) on reducing HIV transmission in addition to already established survival benefits. Given the close interaction of tuberculosis (TB) and HIV epidemics, ART expansion could have important ramifications for TB burden. Previous studies suggest a wide range of possible TB impacts following ART expansion. We used three independently developed TB-HIV models to estimate the TB-related impact of expanding ART in South Africa.Design:We considered two dimensions of ART expansion - improving coverage of pre-ART and ART services, and expanding CD4-based ART eligibility criteria (from CD4