Neurochemical markers do not correlate with cognitive decline in the Lewy body variant of Alzheimer disease.
Neurochemical markers do not correlate with cognitive decline in the Lewy body variant of Alzheimer disease.
复制标题
神经化学标记物与阿尔茨海默病路易体变体的认知能力下降无关。
作者：
M. Sabbagh;J. Corey;P. Tiraboschi;R. G. Thomas;E. Masliah;L. Thal
背景
阿尔茨海默病 (AD) 和路易体变异型 AD (LBV) 患者的新皮质突触和胆碱能功能会降低。这些损失与认知能力下降之间的关系在 AD 患者中经常被报道，但对于 LBV 患者仍不清楚。
目标
旨在研究 LBV 患者疾病进展的临床标志物与通过突触素 (Syn) 水平测量的胆碱乙酰转移酶活性或突触密度之间的关系，并研究这些神经化学标志物之间的关系。
方法
对 41 名尸检确诊（国家老龄化研究所 AD 标准）的 LBV 患者的脑标本进行了检查。回顾了生前最后一次简易精神状态检查和祝福信息记忆集中度测试成绩。通过 Syn 的点免疫结合测定来量化中额突触计数。通过既定方案测定中额皮质的胆碱乙酰转移酶活性。
结果
生前最后一次简易精神状态检查评分与 Syn 水平没有显着相关性 (n = 25, r = 0.25, P = .24)；然而，最后一次简易精神状态检查分数与胆碱乙酰转移酶活性之间的关系有显着的趋势（n = 39，r = 0.31，P = .05）。最后的祝福信息记忆浓度测试分数与 Syn 水平（n = 24，r = -0.17，P = .44）或胆碱乙酰转移酶活性（n = 39，r = -0.16，P = .33）无关。最后，Syn 水平与胆碱乙酰转移酶活性之间仅存在适度的相关性（n = 25，r = 0.38，P = .06），未达到统计学显着性。
结论
与 AD 不同，神经化学标记物似乎与 LBV 认知能力下降没有很好的相关性。
BACKGROUND
Reductions in neocortical synapses and cholinergic function occur in patients with Alzheimer disease (AD) and in patients with the Lewy body variant of AD (LBV). The relation between these losses and cognitive decline has been reported frequently in patients with AD but remains unclear for patients with LBV.
OBJECTIVES
To investigate the relation between clinical markers of disease progression and choline acetyltransferase activity or synaptic density, measured by synaptophysin (Syn) level, in patients with LBV, and to investigate the relation of these neurochemical markers with one another.
METHODS
Brain specimens of 41 patients with autopsy-confirmed (National Institute on Aging criteria for AD) LBV were examined. The last Mini-Mental State Examination and Blessed Information-Memory-Concentration test scores before death were reviewed. Midfrontal synapse counts were quantified by a dot-immunobinding assay for Syn. Choline acetyltransferase activity of the midfrontal cortex was assayed by established protocols.
RESULTS
The last Mini-Mental State Examination score before death did not correlate significantly with Syn level (n = 25, r = 0.25, P = .24); however, there was a trend toward significance for the relation between last Mini-Mental State Examination score and choline acetyltransferase activity (n = 39, r = 0.31, P = .05). The last Blessed Information-Memory-Concentration test score did not correlate with either Syn level (n = 24, r = -0.17, P = .44) or choline acetyltransferase activity (n = 39, r = -0.16, P = .33). Finally, there was only a modest correlation between Syn level and choline acetyltransferase activity (n = 25, r = 0.38, P = .06), which did not reach statistical significance.
CONCLUSION
Unlike AD, neurochemical markers do not appear to correlate well with cognitive decline in LBV.
皮克病的新皮质形态测定和胆碱能神经化学。
DOI：
--
发表时间：
1988
期刊：
The American journal of pathology
影响因子：
--
作者：
Hansen,LA;Deteresa,R;Tobias,H;Alford,M;Terry,RD
通讯作者：
Terry,RD
影响因子：
--
作者：
SAMUEL, W;TERRY, RD;MASLIAH, E
通讯作者：
MASLIAH, E