Glucose-responsive neurons in the brainstem
Glucose-responsive neurons in the brainstem
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DOI：
10.1002/j.1550-8528.1995.tb00493.x
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发表时间：
1995-12-01
期刊：
影响因子：
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通讯作者：
Funahashi, M
中科院分区：
文献类型：
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作者：
Adachi, A;Kobashi, M;Funahashi, M
最后区：啮齿类动物最后区（AP）消融对摄食行为的影响表明该结构参与控制摄食。在AP中鉴定出两种类型的葡萄糖反应神经元：一种特征在于响应于葡萄糖而增加放电速率（葡萄糖受体型）和另一种通过降低响应于葡萄糖的放电速率（葡萄糖敏感型），这些葡萄糖反应神经元可能参与血糖稳态。孤束核：葡萄糖反应神经元位于孤束核尾侧部，是内脏传入的中继站，证实了肝葡萄糖敏感性传入纤维终止于某些葡萄糖敏感神经元，这种会聚可能是一种故障安全机制。涉及兴奋性和抑制性中间神经元的复杂神经网络的NTS可能与血糖信息的整合有关。迷走神经：迷走神经背侧运动核（DMV）内的某些神经元被鉴定为葡萄糖反应性神经元，这两种类型的神经元也被识别。逆行激活证实，这些葡萄糖反应性DMV神经元将其轴突发送到支配胃、肠或胰腺的胃或腹腔分支。它们也可能在脑干神经控制血糖稳态中发挥作用，作为故障安全机制。
Area Postrema: The influence on feeding behavior caused by ablation of the area postrema (AP) in rodents indicates the participation of this structure in the control of ingestion, Two types of glucose responsive neurons were identified in the AP: one is characterized by increasing the discharge rate in response to glucose (glucoreceptor type) and the other by decreasing the discharge rates in response to glucose (glucose sensitive type), These glucose responsive neurons may participate in glycemic homeostasis.Nucleus of Solitary Tract: The glucose responsive neurons exist within the caudal portion of nucleus of the solitary tract (NTS), a relay station in visceral afferents, Two types similar to the AP were also recognized, It is confirmed that hepatic glucose sensitive afferents terminate on some of the glucose sensitive neurons, This convergence may serve as a fail-safe mechanism, In addition, the NTS involving complex neural networks of excitatory and inhibitory interneurons may be concerned with integration of glycemic information.Dorsal Motor Nucleus of Vagus: Some neurons within the dorsal motor nucleus of the vagus (DMV) were identified as the glucose responsive ones, Both types were also recognized, It is confirmed by antidromic activation that these glucose responsive DMV neurons send their axons toward the gastric or coeliac branch that innervates either the stomach, intestine or pancreas, Some of the DMV neurons may subserve an enteroceptor function by themselves, They may also play a role in the brainstem neural control of glycemic homeostasis as the failsafe mechanism.