Creatinine-based equation to estimate the glomerular filtration rate in Japanese children and adolescents with chronic kidney disease
Creatinine-based equation to estimate the glomerular filtration rate in Japanese children and adolescents with chronic kidney disease
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DOI：
10.1007/s10157-013-0856-y
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发表时间：
2014-08-01
影响因子：
2.3
通讯作者：
Honda, Masataka
中科院分区：
文献类型：
--
作者：
Uemura, Osamu;Nagai, Takuhito;Honda, Masataka
肾菊粉清除率是评价肾功能的金标准，但在儿童中不易测量。因此，我们利用基于血清肌酐(Cr)的估计GFR(EGFR)通过酶法测量血清Cr，并报告了日本2至11岁儿童中基于血清Cr的简单EGFR。对131例2~18岁的慢性肾脏病(CKD)患儿的菊粉清除量和血清肌酐水平进行了测定，以确定日本儿童和青少年的血清CrEGFR。我们用多项式公式给出了日本儿童和青少年血清Cr基EGFR的复杂估计公式，以供日本儿童(除婴儿外)参考血肌酐水平。结果表明：参考血清肌酸水平(Y)可用体长(X)的两个方程表示。新的多项式EGFR公式可用于日本2~18岁儿童和青少年的临床肾功能筛查。
Renal inulin clearance is the gold standard for evaluation of kidney function, but cannot be measured easily in children. Therefore, we utilize the serum creatinine (Cr)-based estimated GFR (eGFR) measuring serum Cr by the enzymatic method, and we have reported simple serum Cr-based eGFR in Japanese children aged between 2 and 11 years old. Furthermore, we should use serum Cr-based eGFR in Japanese adolescents as well as children with chronic kidney disease for evaluation of renal function.The inulin clearance and serum Cr level determined by an enzymatic method were measured in 131 pediatric chronic kidney disease (CKD) patients between the ages of 2 and 18 years old with no underlying disease affecting renal function except CKD to determine the serum Cr-based eGFR in Japanese children and adolescents.We offer the complex estimated GFR equation using polynomial formulae for reference serum creatinine levels with body length in Japanese children except infants, resulting in the following equation:Reference serum Cr levels (y) are shown by the following two equations of body length (x):The new polynomial eGFR formula showing the relationship with body length and serum Cr level may be applicable for clinical screening of renal function in Japanese children and adolescents aged between 2 and 18 years.