Extracellular regulation of type IIa receptor protein tyrosine phosphatases: mechanistic insights from structural analyses.
Extracellular regulation of type IIa receptor protein tyrosine phosphatases: mechanistic insights from structural analyses.
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DOI：
10.1016/j.semcdb.2014.09.007
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发表时间：
2015-01
影响因子：
7.3
通讯作者：
Aricescu AR
中科院分区：
文献类型：
--
作者：
Coles CH;Jones EY;Aricescu AR
受体蛋白酪氨酸磷酸酶（RPTPs）具有广泛的细胞信号传导功能。特别是，IIa型RPTP家族成员最近被强调为神经元细胞外相互作用的枢纽，调节神经元的延伸和指导，以及突触组织。本文就IIa型RPTP胞外域结构及其与胞外配体相互作用的结构生物学研究进展作一综述。结构见解与生物物理和细胞研究相结合，使我们能够开始拼凑IIa型RPTP信号转导和整合的分子机制，并为未来的实验验证提出假设。
The receptor protein tyrosine phosphatases (RPTPs) exhibit a wide repertoire of cellular signalling functions. In particular, type IIa RPTP family members have recently been highlighted as hubs for extracellular interactions in neurons, regulating neuronal extension and guidance, as well as synaptic organisation. In this review, we will discuss the recent progress of structural biology investigations into the architecture of type IIa RPTP ectodomains and their interactions with extracellular ligands. Structural insights, in combination with biophysical and cellular studies, allow us to begin to piece together molecular mechanisms for the transduction and integration of type IIa RPTP signals and to propose hypotheses for future experimental validation.