Pathways of human B-lymphocyte activation blocked by B-cell specific monoclonal antibodies.
Pathways of human B-lymphocyte activation blocked by B-cell specific monoclonal antibodies.
复制标题
B 细胞特异性单克隆抗体阻断人 B 淋巴细胞激活途径。
作者：
J. Golay;D. Crawford
本报告中提供的数据表明，针对B细胞特异性表面抗原的抗体可以阻断不同模式的B细胞活化。抗-CD 19抗体HD 37强烈阻断由抗-mu和MLR上清液诱导的胸苷掺入的刺激，并且还部分抑制长期EBV转化的细胞系的生长。另一方面，抗-CD 20抗体B1对抗-mu活化几乎没有影响，但阻止EBV对胸苷掺入和转化的刺激。我们的结论是，不同的机制在B细胞激活抗mu和EBV涉及不同的B细胞表面分子。
The data presented in this report demonstrate that antibodies directed against B-cell specific surface antigens can block different modes of B-cell activation. The anti-CD 19 antibody HD37 strongly blocks the stimulation of thymidine incorporation induced by anti-mu and MLR supernatant and also partially inhibits the growth of long-term EBV-transformed cell lines. The anti-CD20 antibody B1, on the other hand, has little effect on anti-mu activation but prevents the stimulation of thymidine incorporation and transformation by EBV. We conclude that different mechanisms operate during B-cell activation by anti-mu and EBV involving different B-cell surface molecules.