Spontaneously emerging cortical representations of visual attributes
Spontaneously emerging cortical representations of visual attributes
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DOI：
10.1038/nature02078
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发表时间：
2003-10-30
期刊：
影响因子：
64.8
通讯作者：
Arieli, A
中科院分区：
文献类型：
--
作者：
Kenet, T;Bibitchkov, D;Arieli, A
自发的皮质活动--在没有有意的感觉输入的情况下进行的活动--已经被广泛地研究(1)，使用的方法范围从脑电(脑电)(2-4)，到电压敏感的染料成像(5-7)，再到单个神经元的记录(8，9)。正在进行的大脑皮层活动已被证明在发育中起关键作用(10-14)，也必须是处理感官知觉所必需的，因为它调节刺激诱发的活动(5，15，16)，并与行为相关(17)。然而，它在外部信息处理中的作用以及它与感觉属性的内部表征的关系仍不清楚。利用电压敏感染料成像，我们先前在麻醉猫的视觉皮质中正在进行的活动和单个神经元的自发放电之间建立了密切联系(6)。在这里，我们报告了这样的活动包括一组动态转换的皮质状态，其中许多与方位图密切对应。当这种定向状态自发出现时，它跨越几个超柱，并且通常紧随其后的是与近端定向相对应的状态。我们认为，动态切换大脑皮层状态可以代表大脑的内部环境，从而反映或影响记忆、感知和行为。
Spontaneous cortical activity - ongoing activity in the absence of intentional sensory input - has been studied extensively(1), using methods ranging from EEG (electroencephalography)(2-4), through voltage sensitive dye imaging(5-7), down to recordings from single neurons(8,9). Ongoing cortical activity has been shown to play a critical role in development(10-14), and must also be essential for processing sensory perception, because it modulates stimulus-evoked activity(5,15,16), and is correlated with behaviour(17). Yet its role in the processing of external information and its relationship to internal representations of sensory attributes remains unknown. Using voltage sensitive dye imaging, we previously established a close link between ongoing activity in the visual cortex of anaesthetized cats and the spontaneous firing of a single neuron(6). Here we report that such activity encompasses a set of dynamically switching cortical states, many of which correspond closely to orientation maps. When such an orientation state emerged spontaneously, it spanned several hypercolumns and was often followed by a state corresponding to a proximal orientation. We suggest that dynamically switching cortical states could represent the brain's internal context, and therefore reflect or influence memory, perception and behaviour.