TEMPERATURE-DEPENDENCE OF DIPALMITOYL PHOSPHATIDYLCHOLINE MONOLAYER STABILITY
TEMPERATURE-DEPENDENCE OF DIPALMITOYL PHOSPHATIDYLCHOLINE MONOLAYER STABILITY
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DOI：
10.1152/jappl.1981.51.5.1108
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发表时间：
1981-01-01
影响因子：
3.3
通讯作者：
GONZALES, J
中科院分区：
文献类型：
--
作者：
GOERKE, J;GONZALES, J
二棕榈酰磷脂酰胆碱是肺表面活性剂的主要成分，了解其在空气-水界面上作为膜扩散的行为对于理解肺表面活性剂如何工作是必不可少的。研究了二棕榈酰、二肉豆蔻酰和棕榈酰-肉豆蔻酰磷脂酰胆碱在不同温度下的极低表面张力空气-水单分子膜的坍塌速率。在每种情况下，单分子层在3 - 4 ℃突然变得不稳定。C高于它们的本体脂-水相变温度（Tc）。这符合一个可比的增加Tc发生在散装系统进行高压。这些发现也与离体大鼠肺的行为一致，当保持在高于二棕榈酰磷脂酰胆碱的Tc的温度下时，离体大鼠肺需要更高的透壁压以维持给定的放气体积。
Dipalmitoylphosphatidylcholine is the principal component of lung surfactant and knowledge of its behavior as a film spread at the air-water interface is essential for understanding how lung surfactant works. The collapse rates of very low surface tension air-water monolayers of dipalmitoyl, dimyristoyl and palmitoyl-myristoyl phosphatidylcholines were studied at different temperatures. In each case the monolayers became unstable abruptly at temperatures 3-4.degree. C above their bulk lipid-water phase transition temperatures (Tc). This accords with a comparable increase in Tc occurring in bulk systems subjected to high pressure. These findings are also consistent with the behavior of isolated rat lungs, which require higher transmural pressures to maintain a given volume on deflation when kept at temperatures above the Tc of dipalmitoylphosphatidylcholine.