Regiospecifically deuterated (-)-Δ9-tetrahydrocannabivarins
Regiospecifically deuterated (-)-Δ9-tetrahydrocannabivarins
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DOI:
10.1039/b205459k
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发表时间:
2002-01-01
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影响因子:
--
通讯作者:
Makriyannis, A
中科院分区:
文献类型:
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作者:
Nikas, SP;Thakur, GA;Makriyannis, A
Deuterated (-)-Delta(9)-tetrahydrocannabivarins dagger (Delta(9)-THCVs) can be used as markers for confirming the illicit use of marijuana. Here, we first describe an efficient synthesis of side chain deuterated Delta(9)-THCVs from the respective 5-propylresorcinols specifically deuterated at the side chain. Our approach involved the development of optimal, high yield methods for the introduction of deuterium at the C-3' and C-2' position of the side chain.