Regiospecifically deuterated (-)-Δ9-tetrahydrocannabivarins

Regiospecifically deuterated (-)-Δ9-tetrahydrocannabivarins
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DOI:
10.1039/b205459k
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发表时间:
2002-01-01
期刊:
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
影响因子:
--
通讯作者:
Makriyannis, A
Makriyannis, A
中科院分区:
其他
文献类型:
--
作者:
Nikas, SP;Thakur, GA;Makriyannis, A

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氘代 (-)-Delta(9)-四氢大麻二酚匕首 (Delta(9)-THCVs) 可用作确认大麻非法使用的标记。在这里,我们首先描述了从侧链专门氘代的各个 5-丙基间苯二酚有效合成侧链氘代 Delta(9)-THCV。我们的方法涉及开发最佳的高产率方法,用于在侧链的 C-3' 和 C-2' 位置引入氘。
Deuterated (-)-Delta(9)-tetrahydrocannabivarins dagger (Delta(9)-THCVs) can be used as markers for confirming the illicit use of marijuana. Here, we first describe an efficient synthesis of side chain deuterated Delta(9)-THCVs from the respective 5-propylresorcinols specifically deuterated at the side chain. Our approach involved the development of optimal, high yield methods for the introduction of deuterium at the C-3' and C-2' position of the side chain.