MAJOR HISTOCOMPATIBILITY COMPLEX-RESTRICTED ANTIGEN PRESENTATION TO ANTIGEN-REACTIVE T-CELLS BY LYMPHOCYTE-B TUMOR-CELLS
MAJOR HISTOCOMPATIBILITY COMPLEX-RESTRICTED ANTIGEN PRESENTATION TO ANTIGEN-REACTIVE T-CELLS BY LYMPHOCYTE-B TUMOR-CELLS
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DOI：
10.1084/jem.154.5.1419
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发表时间：
1981-01-01
影响因子：
15.3
通讯作者：
WARNER, N
中科院分区：
文献类型：
--
作者：
MCKEAN, DJ;INFANTE, AJ;WARNER, N
辅助细胞的功能是向抗原反应性 T 辅助细胞呈递与主要组织相容性复合体 (MHC) I 区编码的基因产物相关的可溶性蛋白抗原。抗原呈递过程中发生的生化事件没有得到充分记录，主要是因为纯化足够数量的同质抗原呈递细胞存在困难。许多[小鼠]Ia阳性B淋巴细胞肿瘤系能够以MHC限制的方式将可溶性蛋白抗原呈递给抗原反应性连续T细胞系。这些肿瘤细胞的抗原呈递功能的表征表明，肿瘤细胞具有许多以前认为仅限于巨噬细胞的功能性抗原呈递特征。这些肿瘤细胞应该提供有用的模型系统，用于确定抗原摄取和加工过程中发生的生化事件，并确定加工的抗原和这些抗原呈递细胞质膜上的 Ia 分子之间的潜在相互作用。
Accessory cells function to present soluble protein antigens in association with gene products encoded within the I region of the major histocompatibility complex (MHC) to antigen-reactive T helper cells. The biochemical events that occur during antigen presentation are not well-documented primarily because of the difficulties involved in purifying sufficient numbers of homogeneous antigen-presenting cells. A number of [mouse] Ia-positive B lymphocyte tumor lines are capable of presenting soluble protein antigens to antigen-reactive continuous T cell lines in an MHC-restricted fashion. The characterization of the antigen presentation function of these tumor cells indicates that the tumor cells have many of the functional antigen-presenting characteristics previously thought to be limited to macrophages. These tumor cells should provide a useful model system for determining the biochemical events that occur in antigen uptake and processing and for determining the potential interactions between processed antigen and Ia molecules on the plasma membrane of these antigen-presenting cells.