The κ-opioid receptor is involved in the stimulating effect of nicotine on adrenocortical activity but not in nicotine induced anxiety
The κ-opioid receptor is involved in the stimulating effect of nicotine on adrenocortical activity but not in nicotine induced anxiety
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DOI：
10.1016/j.bbr.2005.05.005
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发表时间：
2005-09-08
影响因子：
2.7
通讯作者：
Viveros, MP
中科院分区：
文献类型：
--
作者：
Marco, EM;Llorente, R;Viveros, MP
卡帕 (K) 阿片类药物系统似乎在调节运动和成瘾相关过程中与尼古丁相互作用。在这项研究中，我们研究了卡帕-阿片类药物系统在尼古丁对焦虑和肾上腺皮质活动的影响中可能的影响。在两个不同的实验中，我们分析了尼古丁 (0.5 mg/ka i.p.) 与 kappa-阿片受体拮抗剂去甲二托菲明 (nor-binaltorphimine) (5 mg/kg i.p.) 或 kappa-阿片受体激动剂 U50,488H (1 mg/kg s.c.) 之间可能存在的相互作用。在不同组的动物中进行行为和内分泌实验。将动物暴露于洞板，然后立即暴露于十字迷宫。通过放射免疫测定法测定血清皮质酮水平。尼古丁在十字迷宫中引起类似焦虑的作用，并显着降低洞板活动。十字迷宫中的类焦虑作用并未被任何κ-阿片受体配体改变。尼古丁还诱导皮质酮水平显着增加，而本身不发挥任何作用的κ拮抗剂可以拮抗这种作用。当单独施用时，κ激动剂U50,488H诱导皮质酮浓度显着增加。我们提供了第一个证据证明卡帕阿片受体参与尼古丁对肾上腺皮质活动的刺激作用。 (c) 2005 Elsevier B.V. 保留所有权利。
The kappa (K) opioid system appears to interact with nicotine in the modulation of locomotion and addiction related processes. In this study we have investigated the possible implication of the kappa-opioid system in the effects of nicotine on anxiety and adrenocortical activity. In two different experiments, we analysed the possible interaction between nicotine (0.5 mg/ka i.p.) and either the kappa-opioid receptor antagonist nor-binaltorphimine (5 mg/kg i.p.) or the kappa-opioid receptor agonist U50,488H (1 mg/kg s.c.). Behavioural and endocrine experiments were performed indifferent groups of animals. Animals were exposed to the holeboard immediately followed by the plus-maze. Serum corticosterone levels were determined by radioimmunoassay. Nicotine induced an anxiogenic-like effect in the plus-maze and a significant decrease of holeboard activity. The anxiogenic-like effect in the plus-maze was not modified by any of the kappa-opioid receptor ligands. Nicotine also induced a significant increase in the corticosterone levels, and the kappa antagonist, which did not exert any effect per se, antagonised this effect. The kappa-agonist U50,488H induced a significant increase in corticosterone concentration when administered alone. We provide the first evidence for the involvement of the kappa-opioid receptor in the stimulatory effect of nicotine on adrenocortical activity. (c) 2005 Elsevier B.V. All rights reserved.