Association of Th1 and Th2 cytokines with transient inflammatory reaction during lenalidomide plus dexamethasone therapy in multiple myeloma
Association of Th1 and Th2 cytokines with transient inflammatory reaction during lenalidomide plus dexamethasone therapy in multiple myeloma
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DOI：
10.1007/s12185-013-1321-0
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发表时间：
2013-06-01
影响因子：
2.1
通讯作者：
Abe, Masahiro
中科院分区：
文献类型：
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作者：
Harada, Takeshi;Ozaki, Shuji;Abe, Masahiro
在来那度胺（Len）联合地塞米松（DEX）治疗期间，多发性骨髓瘤（MM）患者亚群报告了一过性炎症反应。在此，我们检测了9例用Len加低剂量DEX治疗的难治性或复发性MM患者的Th 1（IL-2和IFN-γ）和Th 2细胞因子（IL-6和TNF-α）的血清水平。6例患者在开始治疗后显示C反应蛋白（CRP）升高。在这些患者中，IFN-γ和IL-6也分别在两名和三名患者中升高。其余3例患者CRP或这些细胞因子无明显变化。此外，Len增强了正常外周血单个核细胞和患者骨髓单个核细胞中含有原发性骨髓瘤细胞和淋巴细胞的Th 1和Th 2细胞因子的产生。提示Len对Th 1和Th 2细胞因子产生的调节可能参与了MM患者的一过性炎症反应。
Transient inflammatory reactions have been reported in a subpopulation of patients with multiple myeloma (MM) during lenalidomide (Len) plus dexamethasone (DEX) therapy. Here, we examined serum levels of Th1 (IL-2 and IFN-gamma) and Th2 cytokines (IL-6 and TNF-alpha) in nine refractory or relapsed MM patients treated with Len plus low-dose DEX. Six patients showed elevation of C-reactive protein (CRP) after the initiation of therapy. In these patients, IFN-gamma and IL-6 were also elevated in two and three patients, respectively. The remaining three patients showed no appreciable changes in CRP or these cytokines. Furthermore, Len enhanced the production of both Th1 and Th2 cytokines in normal peripheral blood mononuclear cells and in patient bone marrow mononuclear cells containing primary myeloma cells and lymphocytes. These results suggest that the modulation of the Th1 and Th2 cytokine production by Len may contribute to transient inflammatory reaction in MM patients.