Maternal SARS-CoV-2 vaccination and infant protection against SARS-CoV-2 during the first six months of life.
Maternal SARS-CoV-2 vaccination and infant protection against SARS-CoV-2 during the first six months of life.
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孕产妇 SARS-CoV-2 疫苗接种和婴儿在生命前六个月内针对 SARS-CoV-2 的保护。
DOI：
10.1038/s41467-023-36547-4
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发表时间：
2023-02-28
影响因子：
16.6
通讯作者：
Klein, Nicola P.
中科院分区：
文献类型：
--
作者：
Zerbo, Ousseny;Ray, G. Thomas;Fireman, Bruce;Layefsky, Evan;Goddard, Kristin;Lewis, Edwin;Ross, Pat;Omer, Saad;Greenberg, Mara;Klein, Nicola P.
我们对2020年12月15日至2022年5月31日在北加州凯撒医疗机构出生的30311名婴儿进行了母亲接种SARS-CoV-2感染疫苗的有效性研究。采用Cox回归分析，妊娠期接种≥2剂COVID-19疫苗的有效性分别为84%（95%可信区间[CI]: 66,93）、62% （CI: 39,77）和56% (CI: 34,71)，分别为δ变异期0- 2、0- 4和0- 6个月。在Omicron变异期，这三个年龄段的母亲接种疫苗的有效性分别为21% (CI: - 21,48), 14% （CI: - 9,32）和13% （CI: - 3,26）。在整个研究期间，与未接种疫苗的母亲的婴儿相比，接种疫苗的母亲的婴儿在出生后的前6个月内因COVID-19住院的发生率较低（21/10万人年vs 100/10万人年）。母亲接种疫苗具有保护作用，但欧米克隆期的保护作用低于三角洲期。随着婴儿年龄的增长，这两个时期的保护作用都有所下降。本研究调查了孕妇在怀孕期间接种COVID-19疫苗对出生后头六个月婴儿感染的影响。利用来自美国加利福尼亚州的数据，作者发现在三角洲优势时期对感染的保护是很高的，但在欧米克隆时期它下降了。
We examined the effectiveness of maternal vaccination against SARS-CoV-2 infection in 30,311 infants born at Kaiser Permanente Northern California from December 15, 2020, to May 31, 2022. Using Cox regression, the effectiveness of ≥2 doses of COVID-19 vaccine received during pregnancy was 84% (95% confidence interval [CI]: 66, 93), 62% (CI: 39, 77) and 56% (CI: 34,71) during months 0–2, 0–4 and 0- 6 of a child’s life, respectively, in the Delta variant period. In the Omicron variant period, the effectiveness of maternal vaccination in these three age intervals was 21% (CI: −21,48), 14% (CI: −9,32) and 13% (CI: −3,26), respectively. Over the entire study period, the incidence of hospitalization for COVID-19 was lower during the first 6 months of life among infants of vaccinated mothers compared with infants of unvaccinated mothers (21/100,000 person-years vs. 100/100,000 person-years). Maternal vaccination was protective, but protection was lower during Omicron than during Delta. Protection during both periods decreased as infants aged. This study investigates the impact of maternal COVID-19 vaccination during pregnancy on infant infection during the first six months of life. Using data from California, USA, the authors find that protection against infection during the period of Delta dominance was high, but that it declined during the Omicron period.
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影响因子：
5.1
作者：
Danino, Dana;Ashkenazi-Hoffnung, Liat;Diaz, Alejandro;Erps, Amir Dov;Eliakim-Raz, Noa;Avni, Yonat Shemer;Greenberg, David;Givon-Lavi, Noga;Youngster, Ilan
通讯作者：
Youngster, Ilan
BNT162B2 mRNA COVID-19疫苗的安全性和功效。
DOI：
10.1056/nejmoa2034577
发表时间：
2020-12-31
期刊：
The New England journal of medicine
影响因子：
--
作者：
Polack FP;Thomas SJ;Kitchin N;Absalon J;Gurtman A;Lockhart S;Perez JL;Pérez Marc G;Moreira ED;Zerbini C;Bailey R;Swanson KA;Roychoudhury S;Koury K;Li P;Kalina WV;Cooper D;Frenck RW Jr;Hammitt LL;Türeci Ö;Nell H;Schaefer A;Ünal S;Tresnan DB;Mather S;Dormitzer PR;Şahin U;Jansen KU;Gruber WC;C4591001 Clinical Trial Group
通讯作者：
C4591001 Clinical Trial Group
DOI：
10.1056/nejmoa2119451
发表时间：
2022-04-21
期刊：
The New England journal of medicine
影响因子：
--
作者：
Andrews N;Stowe J;Kirsebom F;Toffa S;Rickeard T;Gallagher E;Gower C;Kall M;Groves N;O'Connell AM;Simons D;Blomquist PB;Zaidi A;Nash S;Iwani Binti Abdul Aziz N;Thelwall S;Dabrera G;Myers R;Amirthalingam G;Gharbia S;Barrett JC;Elson R;Ladhani SN;Ferguson N;Zambon M;Campbell CNJ;Brown K;Hopkins S;Chand M;Ramsay M;Lopez Bernal J
通讯作者：
Lopez Bernal J
影响因子：
5.5
作者：
Foppa, Ivo M.;Haber, Michael;Shay, David K.
通讯作者：
Shay, David K.
怀孕期间和早产儿或小于胎龄儿期间接受 COVID-19 疫苗 - 美国八个综合医疗保健组织，2020 年 12 月 15 日至 2021 年 7 月 22 日。
DOI：
10.15585/mmwr.mm7101e1
发表时间：
2022-01-07
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
Lipkind HS;Vazquez-Benitez G;DeSilva M;Vesco KK;Ackerman-Banks C;Zhu J;Boyce TG;Daley MF;Fuller CC;Getahun D;Irving SA;Jackson LA;Williams JTB;Zerbo O;McNeil MM;Olson CK;Weintraub E;Kharbanda EO
通讯作者：
Kharbanda EO