Association Between HLA Haplotypes and Increased Serum Levels of IgG4 in Patients With Primary Sclerosing Cholangitis
Association Between HLA Haplotypes and Increased Serum Levels of IgG4 in Patients With Primary Sclerosing Cholangitis
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DOI：
10.1053/j.gastro.2015.01.041
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发表时间：
2015-05-01
期刊：
影响因子：
29.4
通讯作者：
Hov, Johannes Roksund
中科院分区：
文献类型：
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作者：
Berntsen, Natalie L.;Klingenberg, Olav;Hov, Johannes Roksund
据报道，9%-15%的原发性硬化性胆管炎（PSC）患者血清IgG4水平升高；尚不清楚这种增加是否与发病机制有关。我们对来自挪威、瑞典和美国的PSC患者的HLA复合物进行了遗传分析。我们发现高于参考上限的IgG4水平与特定HLA单倍型之间存在关联。与IgG4未升高的患者相比，这些患者PSC最强危险因子HLA-B*08的出现频率显著降低，而HLA-B*07和HLA-DRB1*15的出现频率显著升高。因此，HLA基因型可能影响血清IgG4浓度，IgG4升高可能是PSC不同表型的标志。
Increased serum levels of IgG4 have been reported in 9%-15% of patients with primary sclerosing cholangitis (PSC); it is not clear whether this increase contributes to pathogenesis. We performed genetic analyses of the HLA complex in patients with PSC from Norway, Sweden, and from the United States. We found an association between levels of IgG4 above the upper reference limit and specific HLA haplotypes. These patients had a significantly lower frequency of the strongest PSC risk factor, HLA-B*08, than patients without increased IgG4, and significantly higher frequencies of HLA-B*07 and HLA-DRB1*15. HLA genotype therefore might affect the serum concentration of IgG4, and increased IgG4 might be a marker of a distinct phenotype of PSC.