INTERCONTINENTAL SPREAD OF NEISSERIA-MENINGITIDIS CLONES OF THE ET-5 COMPLEX
INTERCONTINENTAL SPREAD OF NEISSERIA-MENINGITIDIS CLONES OF THE ET-5 COMPLEX
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DOI：
10.1007/bf00415492
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发表时间：
1987-01-01
期刊：
影响因子：
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通讯作者：
SELANDER, RK
中科院分区：
文献类型：
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作者：
CAUGANT, DA;FROHOLM, LO;SELANDER, RK
通过对688株脑膜炎奈瑟菌15个编码酶的结构基因的等位基因变异的电泳分析，研究了脑膜炎奈瑟菌群体的遗传结构。菌株之间的血清群和血清型差异与酶电泳揭示的群体复杂结构关系不大，这涉及到14个主要的克隆系在一半以上的遗传位点上彼此分化。其中一个谱系的克隆，即ET-5复合体，已被确定为最近在欧洲、南非、拉丁美洲和美国爆发和流行脑膜炎球菌病的病原体。有证据表明ET-5复合物的生物体是通过来自古巴的人类移民到达佛罗里达的。
The genetic structure of populations ofNeisseria meningitidiswas examined by an analysis of electrophoretically demonstrable allelic variation at 15 structural genes encoding enzymes in 688 isolates. Variation among strains in serogroup and serotype has little relationship to the complex structure of populations revealed by enzyme electrophoresis, which involves 14 major lineages of clones diverging from one another at more than half their genetic loci. Clones of one of these lineages, the ET-5 complex, have been identified as the causative agent of recent outbreaks and epidemics of meningococcal disease in Europe, South Africa, Latin America, and the United States. There is evidence that organisms of the ET-5 complex reached Florida via human immigrants from Cuba.