Mechanisms underlying improved recovery of neurological function after stroke in the rodent after treatment with neurorestorative cell-based therapies.
Mechanisms underlying improved recovery of neurological function after stroke in the rodent after treatment with neurorestorative cell-based therapies.
复制标题
DOI：
10.1161/strokeaha.108.533141
复制
发表时间：
2009-03
期刊：
影响因子：
8.3
通讯作者：
Zhang ZG
中科院分区：
文献类型：
--
作者：
Chopp M;Li Y;Zhang ZG
我们讨论了潜在的作用机制，治疗缺血性中风的啮齿动物与外源性细胞的有益影响。提出的基本假设是，所施用的细胞通过刺激实质细胞产生恢复因子来增强神经功能的恢复。这些激活的内源性脑细胞引起脑和脊髓中的白色物质重塑，并在受损脑内产生微环境，其放大脑可塑性并导致卒中后神经功能的改善。
We discuss the mechanisms of action underlying the beneficial effects of treating ischemic stroke in the rodent with exogenously administered cells. The essential hypothesis proposed is that the administered cells enhance recovery of neurological function by stimulating the production of restorative factors by parenchymal cells. These activated endogenous brain cells evoke white matter remodeling in the brain and the spinal cord and generate microenvironments within the injured brain that amplify brain plasticity and lead to improvement in neurological function poststroke.