Effects of mechanical compression on metabolism and distribution of oxygen and lactate in intervertebral disc
Effects of mechanical compression on metabolism and distribution of oxygen and lactate in intervertebral disc
复制标题
DOI：
10.1016/j.jbiomech.2008.02.002
复制
发表时间：
2008-01-01
影响因子：
2.4
通讯作者：
Gu, Wei Yong
中科院分区：
文献类型：
--
作者：
Huang, Chun-Yuh;Gu, Wei Yong
本研究的目的是使用三相理论的新公式来检查机械压迫对椎间盘（IVD）中氧和乳酸代谢和分布的影响。在该研究中，将氧和乳酸的细胞代谢速率并入机械-电化学混合物模型的新开发的公式中[Huang，C.是的，Gu，W.Y.，2007.动态无侧限压缩下荷电水合纤维组织中拉压非线性对溶质输运的影响。Journal of Biomechanical Engineering 129，423-429].该模型被用来数值分析静态或动态压缩下的IVD中的氧和乳酸的代谢和运输。理论分析表明，压力负荷可以影响营养物质的运输和代谢。动态压缩增加了氧浓度，减少了乳酸积累，并促进了氧消耗和乳酸产生（即，能量转换）。动态载荷的这种效应依赖于应变水平和载荷频率，在具有较少渗透性终板的IVD中更明显。相反，静态压缩表现出相反的影响，运输和代谢的氧和乳酸。在这项研究中的理论预测是在很好的协议与文献中。本研究建立了一个新的理论模型，用于分析机械压缩下含水纤维软组织中营养物质的细胞代谢。(c)2008爱思唯尔有限公司保留所有权利。
The objective of this study was to examine the effects of mechanical compression on metabolism and distributions of oxygen and lactate in the intervertebral disc (IVD) using a new formulation of the triphasic theory. In this study, the cellular metabolic rates of oxygen and lactate were incorporated into the newly developed formulation of the mechano-electrochemical mixture model [Huang, C.-Y., Gu, W.Y., 2007. Effect of tension-compression nonlinearity on solute transport in charged hydrated fibrosus tissues under dynamic unconfined compression. Journal of Biomechanical Engineering 129, 423-429]. The model was used to numerically analyze metabolism and transport of oxygen and lactate in the IVD under static or dynamic compression. The theoretical analyses demonstrated that compressive loading could affect transport and metabolism of nutrients. Dynamic compression increased oxygen concentration, reduced lactate accumulation, and promoted oxygen consumption and lactate production (i.e., energy conversion) within the IVD. Such effects of dynamic loading were dependent on strain level and loading frequency, and more pronounced in the IVD with less permeable endplate. In contrast, static compression exhibited inverse effects on transport and metabolism of oxygen and lactate. The theoretical predictions in this study are in good agreement with those in the literature. This study established a new theoretical model for analyzing cellular metabolism of nutrients in hydrated, fibrous soft tissues under mechanical compression. (c) 2008 Elsevier Ltd. All rights reserved.