Recent Advances and Prospects for Multimodality Therapy in Pancreatic Cancer
Recent Advances and Prospects for Multimodality Therapy in Pancreatic Cancer
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DOI：
10.1016/j.semradonc.2016.05.002
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发表时间：
2016-10-01
影响因子：
3.5
通讯作者：
Krishnan, Sunil
中科院分区：
文献类型：
--
作者：
Chadha, Awalpreet S.;Khoo, Allison;Krishnan, Sunil
几十年来，胰腺癌的治疗效果并没有显着改善。然而，最近针对转移性疾病的联合化疗方案取得的有希望的结果增加了人们对未来治疗的乐观态度。随着对明显或隐匿性转移性疾病的更好控制，局部治疗方式的作用可能会扩大，特别是考虑到近三分之一的胰腺癌患者在死亡时患有局部破坏性疾病，而没有远处转移性疾病。技术进步使得剂量递增的放射治疗能够安全地进行，然后可以与化疗、靶向药物、免疫治疗和纳米颗粒药物递送技术相结合，以产生新的和改进的协同效应。在这里，我们讨论胰腺癌多模式治疗的最新进展和未来方向。 (C) 2016 Elsevier Inc. 保留所有权利。
The outcomes for treatment of pancreatic cancer have not improved dramatically in many decades. However, the recent promising results with combination chemotherapy regimens for metastatic disease increase optimism for future treatments. With greater control of overt or occult metastatic disease, there will likely be an expanding role for local treatment modalities, especially given that nearly a third of pancreatic cancer patients have locally destructive disease without distant metastatic disease at the time of death. Technical advances have allowed for the safe delivery of dose-escalated radiation therapy, which can then be combined with chemotherapy, targeted agents, immunotherapy, and nanoparticulate drug delivery techniques to produce novel and improved synergistic effects. Here we discuss recent advances and future directions for multimodality therapy in pancreatic cancer. (C) 2016 Elsevier Inc. All rights reserved.