Malignant mediastinal tumor with bone formation-mesothelioma or sarcoma?
Malignant mediastinal tumor with bone formation-mesothelioma or sarcoma?
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DOI：
10.1097/jto.0b013e318153fd76
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发表时间：
2007-10-01
影响因子：
20.4
通讯作者：
Elmberger, Goeran
中科院分区：
文献类型：
--
作者：
Hillerdal, Gunnar;Elmberger, Goeran
间皮瘤可以出现在不同的变种中，其中一些很难或不可能与肉瘤相鉴别。有零星的肉瘤性间皮瘤有成骨特性的报道。在此，我们报告一位57岁男性患者，其临床表现为纵隔肿瘤内有散在的不规则钙化，右侧胸膜有一些散在增厚的胸膜。活组织检查显示肉瘤伴骨形成。该男子出生在土耳其的Karain村，那里的间皮瘤发病率极高，因此被诊断为肉瘤性间皮瘤。由于肿瘤压迫了大血管和心脏，因此进行了去茎术，随后进行了培奈曲塞和卡铂治疗。然而，肿瘤迅速生长并扩散到胸膜，累及心脏，患者死亡。据我们所知，这是第一例肉瘤性间皮瘤由于环境暴露于矿物纤维而形成骨的报道。
Mesothelioma can occur in different variants, some of which are difficult or impossible to differentiate from sarcomas. There are scattered reports of sarcomatous mesotheliomas that have osteogenic properties. Here, we report a 57-year old man who presented with a mediastinal tumor containing scattered irregular calcifications with some scattered pleural thickening of the right pleura. Biopsy showed a sarcoma with bone formation. The man was born in the Turkish village of Karain, where the incidence of mesothelioma is extremely high, and a sarcomatous mesothelioma was therefore diagnosed. Since the tumor was pressing against the large vessels and heart, a debulking was performed, followed by Pernetrexed and Carboplatin treatment. However, the tumor grew rapidly and spread to the pleura, involved the heart, and the patient succumbed. This is to our knowledge the first report of a sarcomatous mesothelioma with bone formation from environmental exposure to mineral fibers.