Olfactory Performance in AD, aMCI, and Healthy Ageing: A Unirhinal Approach
Olfactory Performance in AD, aMCI, and Healthy Ageing: A Unirhinal Approach
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DOI：
10.1093/chemse/bjq094
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发表时间：
2010-11-01
期刊：
影响因子：
3.5
通讯作者：
Savage, Greg
中科院分区：
文献类型：
--
作者：
Bahar-Fuchs, Alex;Moss, Simon;Savage, Greg
嗅觉功能障碍是阿尔茨海默病 (AD) 的最早症状之一，并且已在患有遗忘性轻度认知障碍 (aMCI) 的个体中得到证实。 aMCI 患者嗅觉障碍的严重程度是否与 AD 患者相似尚未明确。此外，鉴于早期 AD 神经病理学负担不对称的报道，如果对嗅觉功能进行非鼻评估，嗅觉表现的功能不对称可能会增强早期发现。我们比较了 AD、aMCI 和健康参与者的嗅觉识别和非鼻评估记忆能力。嗅觉识别在健康参与者中最为熟练，而在 AD 中最不熟练，尽管这种差异并不取决于鼻孔一侧。然而，当分析中仅包括每位参与者最差的鼻孔时，aMCI 患者的表现优于 AD 患者。相比之下，当分析中仅包括每个参与者的最佳鼻孔时（通常被视为对鼻性能的估计），aMCI 和 AD 之间的这种差异就消失了。各组之间的嗅觉记忆没有显着差异，这可能反映了地板效应。研究结果支持这样的假设：非嗅觉评估可能有助于区分痴呆和非痴呆个体。
Olfactory dysfunction constitutes one of the earliest signs of Alzheimer's disease (AD) and has been shown in individuals with amnestic mild cognitive impairment (aMCI). Whether the severity of olfactory impairments in aMCI patients parallels those in AD has not been clearly established. In addition, given reports of asymmetries in neuropathological burden in early AD, functional asymmetries in olfactory performance may enhance early detection if olfactory function is assessed unirhinally. We compared AD, aMCI, and healthy participants on olfactory identification and memory assessed unirhinally. Olfactory identification was most proficient in the healthy participants and least proficient in AD, although this disparity did not depend on nostril side. Nevertheless, when only the worst nostril of each participant was included in the analysis, aMCI patients outperformed their AD counterparts. In contrast, when only the best nostril of each participant was included in the analysis-often regarded as an estimate of birhinal performance-this difference between aMCI and AD dissipated. Olfactory memory did not differ significantly across the groups, perhaps reflecting a floor effect. The findings support the hypothesis that unirhinal olfactory assessment may assist in differentiating between demented and nondemented individuals.