Expired air carbon monoxide, smoking, and other variables. A community study.
Expired air carbon monoxide, smoking, and other variables. A community study.
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呼出空气一氧化碳、吸烟和其他变量。
DOI：
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发表时间：
1973
期刊：
影响因子：
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通讯作者：
Holland
中科院分区：
文献类型：
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作者：
J. Rea;P. Tyrer;H. Kasap;Shirley A. A. Beresford;Jones;London N W;Denmark Hill;London S E;Holland Adler;Holland
分析呼出的空气中的一氧化碳含量现在是人口研究中常用的一种技术。1958年，Jones、Ellicott、Cadigan和Gaensler首次证明它与血液中的碳氧血红蛋白浓度密切相关。英国(泰尔，1964)和美国(Ringold等人，1962；Goldsmith，Schuette和Novick，1963)的研究表明，它还与吸烟以及暴露在一氧化碳大气污染中有关。香烟烟雾中的一氧化碳浓度在2%或更高时，可导致每天吸烟15支或更多香烟的人的碳氧血红蛋白水平高达总血红蛋白的12%(Goldsmith和Landaw，1968)。有一些证据表明，碳氧血红蛋白水平超过5%可能会对良好的视觉和听觉辨别产生不利影响(Macfarland，Roughton，Halperin和Niven，1944；Beard和Wertheim，1967；Schulte，1963)。最近有人提出，吸烟与缺血性心脏病之间的关系也可能与一氧化碳的作用有关(Goldsmith and Landaw，1968；Goldsmith，1969；Astrup，Kjeldsen，and Wanstrup，1967；Astrup，1969)；以及孕期吸烟与低出生体重之间的关系(Astrup，Troll，Olsen，and Kjeldsen，1972)。本文基于1967年兰贝斯社区心肺疾病研究的结果，其中进行了各种心肺测试，包括呼出空气中的一氧化碳水平(Holland和Waller，1971)。它提供了后一种测试的实验细节，并描述了呼出空气中的一氧化碳水平、吸烟、缺血性心脏病和其他因素之间的关系。
Analysis of the carbon monoxide content of expired air is now a frequently used technique in population studies. Its close correlation with the blood concentration of carboxyhaemoglobin was first demonstrated by Jones, Ellicott, Cadigan, and Gaensler in 1958. Studies in the United Kingdom (Tyrer, 1964) and the United States (Ringold et al., 1962; Goldsmith, Schuette, and Novick, 1963) have shown that it is also associated with cigarette smoking as well as exposure to atmospheric pollution with carbon monoxide. The carbon monoxide in cigarette smoke, present in concentrations of 2% or more, can give rise to carboxyhaemoglobin levels of up to 12% of total haemoglobin in individuals smoking 15 or more cigarettes per day (Goldsmith and Landaw, 1968). There is some evidence that carboxyhaemoglobin levels greater than 5% may have adverse effects on fine visual and aural discrimination (Macfarland, Roughton, Halperin, and Niven, 1944; Beard and Wertheim, 1967; Schulte, 1963). It has been suggested recently that the effect of carbon monoxide might also be involved in the relationship between cigarette smoking and ischaemic heart disease (Goldsmith and Landaw, 1968; Goldsmith, 1969; Astrup, Kjeldsen, and Wanstrup, 1967; Astrup, 1969) and in the relationship between smoking in pregnancy and low birth weight (Astrup, Trolle, Olsen, and Kjeldsen, 1972). This paper is based on the results of a community study of cardiorespiratory disease in Lambeth in 1967, in which various cardiorespiratory tests were carried out, including carbon monoxide levels of expired air (Holland and Waller, 1971). It gives the experimental details of the latter test and describes the relationship between carbon monoxide levels in expired air, smoking, ischaemic heart disease, and other factors.