Epigenomics of centromere assembly and function.
Epigenomics of centromere assembly and function.
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DOI：
10.1016/j.ceb.2010.07.002
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发表时间：
2010-12
影响因子：
7.5
通讯作者：
Kaitlin M. Stimpson;B. Sullivan
中科院分区：
文献类型：
--
作者：
Kaitlin M. Stimpson;B. Sullivan
The centromere is a complex chromosomal locus where the kinetochore is formed and microtubules attach during cell division. Centromere identity involves both genomic and sequence-independent (epigenetic) mechanisms. Current models for how centromeres are formed and, conversely, turned off have emerged from studies of unusual or engineered chromosomes, such as neocentromeres, artificial chromosomes, and dicentric chromosomes. Recent studies have highlighted the importance of unique chromatin marked by the histone H3 variant CENP-A, classical chromatin (heterochromatin and euchromatin), and transcription during centromere activation and inactivation. These advances have deepened our view of what defines a centromere and how it behaves in various genomic and chromatin contexts.
