INTRACEREBRAL POTENTIALS TO RARE TARGET AND DISTRACTER AUDITORY AND VISUAL-STIMULI .1. SUPERIOR TEMPORAL PLANE AND PARIETAL LOBE
INTRACEREBRAL POTENTIALS TO RARE TARGET AND DISTRACTER AUDITORY AND VISUAL-STIMULI .1. SUPERIOR TEMPORAL PLANE AND PARIETAL LOBE
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DOI：
10.1016/0013-4694(94)00259-n
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发表时间：
1995-03-01
期刊：
影响因子：
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通讯作者：
MUSOLINO, A
中科院分区：
文献类型：
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作者：
HALGREN, E;BAUDENA, P;MUSOLINO, A
记录了 41 名患者颞上平面和顶叶 537 个部位的事件相关电位。在手术治疗前植入深度电极以定位癫痫发作源头。受试者接受了带有目标和非目标罕见刺激的听觉辨别任务（“标准奇怪范式”）。在某些情况下，目标音、干扰音和频繁音调在音高和音量方面完全平衡。变体包括类似的视觉辨别任务或听觉任务，其中罕见的目标事件是音调的省略，或在一系列交替音调中重复一个音调。在一些受试者中，传递了相同的听觉刺激，但患者在阅读时忽略了它们。可以根据波形、潜伏期和任务相关性来区分三种一般反应模式。首先，在后上颞平面中观察到与稀有性本身明显相关的电位，而不是感觉特征或习惯性的差异，从早期成分上叠加的大量积极性开始。这种积极性在刺激开始后 150 毫秒时达到峰值，并在外侧裂上方的部位反转。随后的分量可能很大、焦点和/或极性反转，并且通常包括 230 毫秒的正性和 330 毫秒的负性。该区域的所有组件均特定于听觉形态。其次，在后扣带回和边缘上回中，观察到尖锐的三相负-正-负波形，其峰值在约210-300-400毫秒处。这种波形的幅度相对较小且弥散，且极性很少反转。它是多模态的，但对听觉刺激最为突出，当刺激被忽略时似乎仍然存在，并且对重复的单词和面孔不明显。第三，在顶叶上叶观察到宽阔的、通常是单相的波形，峰值时间约为 380 毫秒，与海马体中记录的波形类似。这种波形可能具有很大的振幅，通常是高度聚焦的，并且可以在短距离内反转。它等同于视觉和听觉刺激，也是通过重复单词和面孔引起的。听觉皮层的早期内源性活动可能体现出先于多模式关联皮层其他模式的活动。 “三相”模式可能体现了弥漫性非特异性定向反应，这也反映在头皮 P3a 中。后期的广泛模式可能体现了认知闭合，这也反映在头皮 P3b 或晚期阳性成分中。
Event-related potentials were recorded from 537 sites in the superior temporal plane and parietal lobe of 41 patients. Depth electrodes were implanted to localize seizure origin prior to surgical treatment. Subjects received an auditory discrimination task with target and non-target rare stimuli (''standard oddball paradigm''). In some cases, the target, distracting and frequent tones were completely balanced across blocks for pitch and volume. Variants included an analogous visual discrimination task, or auditory tasks where the rare target event was the omission of a tone, or the repetition of a tone within a series of alternating tones. In some subjects, the same auditory stimuli were delivered but the patient ignored them while reading.Three general response patterns could be distinguished on the basis of their wave forms, latencies and task correlates. First, potentials apparently related to rarity per se, as opposed to differences in sensory characteristics, or in habituation, were observed in the posterior superior temporal plane, beginning with a large positivity superimposed on early components. This positivity peaked at 150 msec after stimulus onset and inverted in sites superior to the Sylvian fissure. Subsequent components could be large, focal and/or inverting in polarity, and usually included a positivity at 230 msec and a negativity at 330 msec. All components in this area were specific to the auditory modality. Second, in the posterior cingulate and supramarginal gyri, a sharp triphasic negative-positive-negative wave form with peaks at about 210-300-400 msec was observed. This wave form was of relatively small amplitude and diffuse, and seldom inverted in polarity. It was multimodal but most prominent to auditory stimuli, appeared to remain when the stimuli were ignored, and was not apparent to repeated words and faces. Third, a broad, often monophasic, wave form peaking at about 380 msec was observed in the superior parietal lobe, similar to that which has been recorded in the hippocampus. This wave form could be of large amplitude, often highly focal, and could invert over short distances. It was equal to visual and auditory stimuli and was also evoked by repeating words and faces.The early endogenous activity in auditory cortex may embody activity that is antecedent to the other patterns in multimodal association cortex. The ''triphasic'' pattern may embody a diffuse non-specific orienting response that is also reflected in the scalp P3a. The later broad pattern may embody the cognitive closure that is also reflected in the scalp P3b or late positive component.