Bone metabolism and the cardiometabolic syndrome: pathophysiologic insights.
Bone metabolism and the cardiometabolic syndrome: pathophysiologic insights.
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DOI：
10.1111/j.0197-3118.2006.05457.x
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发表时间：
2006-01-01
期刊：
影响因子：
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通讯作者：
McFarlane, Samy I
中科院分区：
文献类型：
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作者：
McFarlane, Samy I
越来越多的证据表明，心脏代谢综合征的几个组成部分，如高血压，甘油三酯升高和高密度脂蛋白胆固醇降低也是低骨密度的危险因素。此外，心脏代谢综合征中动脉粥样硬化的一些潜在危险因素，如炎症，也在骨质疏松症（最常见的代谢性骨病）的发病机制中起主要作用。在这篇文章的首发杂志的代谢综合征，作者提出了目前的证据的相互作用的骨代谢和心血管代谢综合征，突出了在这一领域的主要研究和讨论的潜力，将是有用的治疗药物，在治疗骨质疏松症以及动脉粥样硬化。
Accumulating evidence indicates that the several components of the cardiometabolic syndrome such as hypertension, increased triglycerides, and reduced high-density lipoprotein cholesterol are also risk factors for low bone mineral density. Furthermore, some of the underlying risk factors for atherosclerosis in the cardiometabolic syndrome, such as inflammation, also play a major role in the pathogenesis of osteoporosis, the most common metabolic bone disease. In this article for the premiere issue of the Journal of the CardioMetabolic Syndrome, the author presents the current evidence of the interaction of bone metabolism and the cardiometabolic syndrome, highlighting the major research in this area and discussing the potential of therapeutic agents that will be useful in the treatment of osteoporosis as well as atherosclerosis.