Major Depressive Disorder Among HIV Infected Youth in Uganda: Incidence, Persistence and Their Predictors
Major Depressive Disorder Among HIV Infected Youth in Uganda: Incidence, Persistence and Their Predictors
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DOI：
10.1007/s10461-020-02815-3
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发表时间：
2020-02-20
影响因子：
4.4
通讯作者：
Patel, Vikram
中科院分区：
文献类型：
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作者：
Kinyanda, Eugene;Salisbury, Tatiana T.;Patel, Vikram
在乌干达的儿童和青少年与艾滋病毒（CA-HIV）的严重抑郁症（MDD）的发病率和持续性进行了说明。共纳入1339名CA-HIV护理人员，随访12个月。使用DSM-5参考儿童和青少年症状量表-5（CASI-5）评估MDD，基线时MDD的患病率为5%（95% CI 3.3-7.3）。采用Kaplan-Meir法估计MDD的发生率，并拟合考克斯模型以探讨MDD发生的预测因素。12个月内MDD的累积发生率为7.6/100人-年（95% CI：6.2-9.4），持续性MDD发生率为10/105（9.5% CI：3.9-15.1）。事件MDD的重要独立预测因素是：CA-HIV的最高教育水平（保护性），抑郁评分增加和CD 4最低点降低。这些发现有什么应该构成艾滋病毒青年服务的心理健康整合模式的组成部分，并为个性化的心理健康护理的未来发展的影响。
Incidence and persistence of major depressive disorder (MDD) in children and adolescents with HIV (CA-HIV) in Uganda is described. 1339 CA-HIV attending care were enrolled and followed up for 12 months. MDD was assessed using the DSM-5 referenced Child and Adolescent Symptom Inventory-5 (CASI-5), with a prevalence for MDD at baseline of 5% (95% CI 3.3-7.3). Kaplan-Meir method was used to estimate incidence of MDD and Cox models were fitted to investigate predictors of incident MDD. Cumulative incidence of MDD over 12 months was 7.6 per 100 person-years 95% CI (6.2-9.4) and a rate of persistent MDD of 10/105 (9.5% CI 3.9-15.1). Significant independent predictors of incident MDD were: highest educational level of CA-HIV (protective), increasing depressive scores and decreasing CD4 Nadir. These finding have implications for what should constitute components of a mental health integration model in HIV youth services and for the future development of individualised mental health care.