Germacrane-type sesquiterpenoids with cytotoxic activity from Sigesbeckia orientalis
Germacrane-type sesquiterpenoids with cytotoxic activity from Sigesbeckia orientalis
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东方茭白具有细胞毒活性的香叶兰型倍半萜类化合物
DOI：
10.1016/j.bioorg.2019.103196
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发表时间：
2019-11-01
影响因子：
5.1
通讯作者：
Zhang, Hua
中科院分区：
文献类型：
--
作者：
Liu, Na;Wu, Cong;Zhang, Hua
从Sigesbeckia orientalis地上部分分离得到11个新的高氧吉根烷型倍半萜（1-11）和16个已知类似物（12-27）。通过核磁共振和电子捕获检测等波谱分析方法确定了它们的结构，包括绝对构型。具有8-甲基丙烯酰氧基的化合物13、21和23显示出比其它共代谢物更强的对人A549和MDA-MB-231癌细胞系的体外细胞毒性，IC 50值范围为6.02至10.77 μ M，与阳性对照阿霉素相当。
Eleven new highly oxygenated germacrane-type sesquiterpenoids (1-11) and 16 known analogues (12-27) were isolated from the aerial parts of Sigesbeckia orientalis. Their structures, including absolute configurations, were determined by comprehensive spectroscopic methods especially NMR and ECD analyses. Compounds 13, 21 and 23 possessing an 8-methacryloxy group showed stronger in vitro cytotoxicity against human A549 and MDA-MB-231 cancer cell lines than other co-metabolites, with IC50 values ranging from 6.02 to 10.77 mu M comparable to the positive control adriamycin.