Nanoantioxidant-Based Silica Particles as Flavonoid Carrier for Drug Delivery Applications
Nanoantioxidant-Based Silica Particles as Flavonoid Carrier for Drug Delivery Applications
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DOI：
10.3390/pharmaceutics12040302
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发表时间：
2020-04-01
期刊：
影响因子：
5.4
通讯作者：
Morales, Javier
中科院分区：
文献类型：
--
作者：
Arriagada, Francisco;Guenther, German;Morales, Javier
在药物制剂中使用的纳米系统在增强难以配制的药物的给药方面显示出有希望的结果。特别是，多孔二氧化硅纳米颗粒已被证明具有在生物系统中应用的优异性能;然而，仍然存在与开发更有效和生物相容性材料相关的几个挑战。一个有趣的方法，以提高这些纳米材料的纳米抗氧化剂载体的发展。在这项工作中，杂化纳米抗氧化剂载体的基础上，多孔二氧化硅纳米平台与迷迭香酸抗氧化剂固定在其表面上的开发和表征。采用动态光散射（DLS）、zeta电位、透射电子显微镜（TEM）、N-2吸附-脱附测量、差示扫描量热法（DSC）、傅里叶变换红外光谱（FT-IR）和2，2-二苯基-1-苦基肼（DPPH.）测定用于表征和评价纳米载体的抗氧化活性。此外，使用两种生物相关介质评价药物释放曲线。迷迭香酸的抗氧化活性得到保持，表明该部分的正确配置。动力学研究表明，更多的桑色素在模拟肠液中释放比在胃的，而一个异常的非Fickian释放机制观察。这些结果表明，一个有前途的抗氧化剂纳米载体，适合于未来的药物输送应用。
Nanosystems used in pharmaceutical formulations have shown promising results in enhancing the administration of drugs of difficult formulations. In particular, porous silica nanoparticles have demonstrated excellent properties for application in biological systems; however, there are still several challenges related to the development of more effective and biocompatible materials. An interesting approach to enhance these nanomaterials has been the development of nanoantioxidant carriers. In this work, a hybrid nanoantioxidant carrier based on porous silica nanoplatform with rosmarinic acid antioxidant immobilized on its surface were developed and characterized. Techniques such as dynamic light scattering (DLS), zeta potential, transmission electron microscopy (TEM), N-2 adsorption-desorption measurements, differential scanning calorimetry (DSC), Fourier transform-infrared spectroscopy (FT-IR), and 2,2-diphenyl-1-picrylhydrazyl (DPPH.) assay were used to characterize and evaluate the antioxidant activity of nanocarriers. In addition, drug release profile was evaluated using two biorelevant media. The antioxidant activity of rosmarinic acid was maintained, suggesting the correct disposition of the moiety. Kinetic studies reveal that more morin is released in the simulated intestinal fluid than in the gastric one, while an anomalous non-Fickian release mechanism was observed. These results suggest a promising antioxidant nanocarrier suitable for future application in drug delivery.