First national tuberculin survey in Viet Nam: characteristics and association with tuberculosis prevalence
First national tuberculin survey in Viet Nam: characteristics and association with tuberculosis prevalence
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DOI：
10.5588/ijtld.12.0200
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发表时间：
2013-06-01
影响因子：
4
通讯作者：
Tiemersma, E. W.
中科院分区：
文献类型：
--
作者：
Hoa, N. B.;Cobelens, F. G. J.;Tiemersma, E. W.
目的：估计结核分枝杆菌感染的患病率和结核感染的年度风险（阿尔蒂），并将其与结核病（TB）的患病率进行比较，研究集群和households.METHODS：在2006-2007年在越南进行了一项全国性的分层集群抽样调查，以评估结核分枝杆菌感染的患病率。结核6-14岁儿童的代表性样本进行了结核菌素皮肤试验（TST）使用Mantoux方法。结果：23 160名儿童登记，21 487（92.8%）进行了测试和阅读，并可用于分析。使用10 mm的临界点，TST阳性的估计患病率为16.7%，阿尔蒂为1.7%（95%CI 1.5-1.8）。城市的感染率高于农村和偏远地区，感染率随着年龄的增长而增加。结核病患病率与聚集性感染之间存在显著相关性（回归系数0.54，95%CI0.06 -1.01，P = 0.027，相关系数R2 = 0.120）。有结核病史的儿童TST阳性率是无结核病史儿童的1.6倍（P < 0.05）。结论：全国阿尔蒂结核感染率为1.7%。TST阳性与家庭中存在结核病病例相关。
OBJECTIVES: To estimate the prevalence of infection with Mycobacterium tuberculosis and the annual risk of tuberculous infection (ARTI) and to compare this with the prevalence of tuberculosis (TB) over study clusters and households.METHODS: A nationwide, stratified cluster sample survey was carried out in 2006-2007 in Viet Nam to assess the prevalence of infection with M. tuberculosis. A representative sample of children aged 6-14 years underwent a tuberculin skin test (TST) using the Mantoux method.RESULTS: Of 23 160 children registered, 21 487 (92.8%) were tested and read and available for analysis. Using a cut-off point of 10 mm, the estimated prevalence of TST positivity was 16.7%, and the ARTI was 1.7% (95%CI 1.5-1.8). Higher infection rates were found in urban than in rural and remote areas, and infection rates increased with age. There was significant association between the prevalence of TB disease and infection at the cluster level (regression coefficient 0.54, 95 %CI 0.06-1.01, P = 0.027, correlation coefficient R-2 0.120). Children with a (recent) case of TB in the household were 1.6 times more likely to be TST-positive than children in households with no recent cases (P < 0.05).CONCLUSION: The estimated nationwide ARTI was 1.7%. TST positivity was associated with the presence of a TB case in the household.