Progressive outer retinal necrosis syndrome: a comprehensive review of its clinical presentation, relationship to immune system status, and management.
Progressive outer retinal necrosis syndrome: a comprehensive review of its clinical presentation, relationship to immune system status, and management.
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DOI：
10.1016/s0953-4431(00)00052-7
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发表时间：
2000-12-01
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影响因子：
--
通讯作者：
Austin
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作者：
Austin
进行性外视网膜坏死（PORN）综合征是水痘带状疱疹病毒（VZV）脉络膜视网膜炎的一种形式，几乎只在获得性免疫缺陷综合征（AIDS）患者中发现。这种破坏性的感染有一个非常迅速的过程，可能会导致受影响的眼睛在几天或几周内没有光感。对它的治疗尝试取得了有限的成功。孔源性视网膜脱离常发生在萎缩性视网膜裂孔形成后，硅油填充是最成功的复位方法。不幸的是，这种手术后形成白内障是常见的。PORN需要与急性视网膜坏死（ARN）综合征（一种也可由VZV引起的坏死性视网膜炎）相鉴别。PORN和ARN位于坏死性疱疹性视网膜病变（NHR）谱的两端，其临床表现取决于免疫系统状态。经过简短的病例介绍，PORN的区别临床特点，它从ARN的区别，试图在其治疗，免疫系统状态的作用，其临床表现和治疗，以及并发症的管理，如视网膜脱离和随后的白内障进行了讨论。
Progressive outer retinal necrosis (PORN) syndrome is a form of the Varicella zoster virus (VZV) chorioretinitis found almost exclusively in people with the acquired immunodeficiency syndrome (AIDS). This destructive infection has an extremely rapid course that may lead to no light perception in affected eyes within days or weeks. Attempts at its treatment have had limited success. Rhegmatogenous retinal detachments often occur after the development of atrophic retinal holes, and silicone oil temponade has been found to be the most successful reattachment procedure. Unfortunately, cataract formation is common after such surgery. PORN needs to be differentiated from acute retinal necrosis (ARN) syndrome, a necrotizing retinitis that can also be caused by VZV. PORN and ARN are found at opposite ends of the spectrum of necrotizing herpetic retinopathies (NHR), where its clinical presentation depends upon immune system status. After a brief case presentation, the distinguishing clinical characteristics of PORN, its differentiation from ARN, attempts at its treatment, the role of the immune system status on its clinical appearance and treatment, and management of complications such as retinal detachment and subsequent cataracts are discussed.