Adiponectin expression from human adipose tissue -: Relation to obesity, insulin resistance, and tumor necrosis factor-α expression
Adiponectin expression from human adipose tissue -: Relation to obesity, insulin resistance, and tumor necrosis factor-α expression
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DOI：
10.2337/diabetes.52.7.1779
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发表时间：
2003-07-01
期刊：
影响因子：
7.7
通讯作者：
Ranganathan, G
中科院分区：
文献类型：
--
作者：
Kern, PA;Di Gregorio, GB;Ranganathan, G
脂联素是一种 29 kDa 的脂肪细胞蛋白，与肥胖和脂肪营养不良的胰岛素抵抗有关。为了更好地了解脂联素表达的调节，我们测量了具有不同程度肥胖和胰岛素抵抗的非糖尿病受试者的血浆脂联素和脂肪组织脂联素 mRNA 水平。血浆脂联素和脂联素 mRNA 水平彼此高度相关（r = 0.80，P < 0.001），并且肥胖受试者表达的脂联素水平显着较低。然而，观察到脂联素表达存在显着的性别差异，特别是在相对瘦的受试者中。当男性和女性具有 BMI 时
Adiponectin is a 29-kDa adipocyte protein that has been linked to the insulin resistance of obesity and lipodystrophy. To better understand the regulation of adiponectin expression, we measured plasma adiponectin and adipose tissue adiponectin mRNA levels in nondiabetic subjects with varying degrees of obesity and insulin resistance. Plasma adiponectin and adiponectin mRNA levels were highly correlated with each other (r = 0.80, P < 0.001), and obese subjects expressed significantly lower levels of adiponectin. However, a significant sex difference in adiponectin expression was observed, especially in relatively lean subjects. When men and women with a BMI