Effects of antipsychotic drugs on the long-term effects of amphetamine on nigro-striatal dopamine neurons in iprindole-treated rats
Effects of antipsychotic drugs on the long-term effects of amphetamine on nigro-striatal dopamine neurons in iprindole-treated rats
复制标题
抗精神病药物对安非他明对伊普林多治疗大鼠黑质纹状体多巴胺神经元长期影响的影响
DOI：
10.1007/bf00495943
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
L. Steranka
中科院分区：
文献类型：
--
作者：
L. Steranka
单次注射硫酸苯丙胺(9.2 mg/kg)给伊普利多(10 mg/kg)组大鼠1周后纹状体多巴胺(DA)的减少可被氟哌啶醇(0.2 mg/kg)、舒必利(32 mg/kg)、匹莫齐特(2 mg/kg)、盐酸氯丙嗪(3.5 mg/kg)预防。2-氟奋乃静(0.25 mg/kg)和(+)-丁胺醇(1 mg/kg)，而不是(−)-丁拉莫(1 mg/kg)或氯氮平(40 mg/kg)。相同剂量的舒必利不能显著减轻(+)-苯丙胺硫酸盐(9.2 mg/kg)诱导的单侧纹状体吸入性损伤大鼠的旋转行为。氟哌啶醇(1 mg/kg)、舒必利(32 mg/kg)、匹莫齐特(2 mg/kg)或氯氮平(40 mg/kg)合用不改变硫酸苯丙胺(9.2 mg/kg)给药后8h大鼠脑内苯丙胺浓度。氟哌啶醇(0.2 mg/kg)和舒必利(32 mg/kg)可促进α-甲基-m-酪氨酸(α)耗竭后纹状体DA的恢复，而氯氮平(40 mg/kg)不能促进纹状体DA的恢复。本文讨论了抗精神病药通过影响神经冲动和囊泡递质的中枢性释放来拮抗αMMT引起的纹状体DA的短期耗竭和安非他明引起的纹状体DA的长期耗竭的可能性。
SummaryThe decrease in striatal dopamine (DA) at 1 week after the administration of a single injection of (+)-amphetamine sulfate (9.2 mg/kg) to iprindole-treated (10 mg/kg of iprindole hydrochloride) rats was prevented by haloperidol (0.2 mg/kg), sulpiride (32 mg/kg), pimozide (2 mg/kg), chlorpromazine hydrochloride (3.5 mg/kg), fluphenazine 2-hydrochloride (0.25 mg/kg) and (+)-butaclamol hydrochloride (1 mg/kg) but not by (−)-butaclamol hydrochloride (1 mg/kg) or clozapine (40 mg/kg). The same dose of sulpiride did not significantly attenuate the rotational behavior induced by the administration of (+)-amphetamine sulfate (9.2 mg/kg) to iprindole-treated rats with unilateral aspiration lesions of the striatum. The concentration of amphetamine in the brains of iprindole-treated rats at 8 h after (+)-amphetamine sulfate (9.2 mg/kg) administration was not altered by the coadministration of haloperidol (1 mg/kg), sulpiride (32 mg/kg), pimozide (2 mg/kg) or clozapine (40 mg/kg). Recovery of striatal DA after depletion by α-methyl-m-tyrosine (αMMT) (50 mg/kg) was facilitated by haloperidol (0.2 mg/kg) and sulpiride (32 mg/kg) but not by clozapine (40 mg/kg). The possibility that neuroleptic drugs antagonize both the shortterm depletion of striatal DA produced by αMMT and the long-term depletion of striatal DA produced by amphetamine in iprindole-treated rats by an effect on the nerve impulsemediated release of vesicular transmitter is discussed.
影响因子：
5.2
作者：
Li, Ming-Jun;Ma, Feng-Wang;Pu, Fei
通讯作者：
Pu, Fei