[Cancer-associated carbohydrate antigens available for serum diagnosis].
[Cancer-associated carbohydrate antigens available for serum diagnosis].
复制标题
[可用于血清诊断的癌症相关糖抗原]。
DOI：
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
N. Hattori
中科院分区：
文献类型：
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作者：
N. Sawabu;Y. Takemori;Y. Satomura;H. Watanabe;H. Kawakami;N. Hattori
近年来发展起来的肿瘤单克隆抗体检测抗原中，有许多是糖链抗原，且常与血型物质相关。通过免疫组织学研究，我们主要评估了分类为1型糖链的CA-50、分类为2型糖链的唾液酸SSEA-1和结构未确定的ST-439的血清测定的临床有用性和意义，以及它们的临床病理学意义。此外，还对胰液中CA 19-9和ST-439的测定价值进行了探讨.血清CA-50在胰腺癌和胆道癌中的检出率最高（86%和66%），而在良性疾病中的检出率相对较低。此外，CA-50作为肿瘤标志物的阳性和特异性不低于CA 19-9。然而，在相同的样品中，CA-50与CA 19-9的血清水平的比较显示在恶性疾病中高度正相关。因此，通过CA-50和CA 19-9的组合测定来提高诊断率似乎是不可能的。血清学和免疫组织学研究均表明，唾液酸化SSEA-1和ST-439对肿瘤具有高度特异性，但它们在血清或肿瘤中的出现率低于携带1型糖链的CA 19-9或CA-50。此外，在CA 19-9或CA-50阴性的患者中发现了相当数量的唾液酸化SSEA-1或ST-439阳性患者。这些结果表明，唾液酸SSEA-1或ST-439的测定与CA 19-9或CA-50组合提高了诊断率。虽然胰腺癌患者的胰液中CA 19-9的浓度最高，但慢性胰腺炎患者的浓度也显著高于对照组。此外，癌症患者和慢性胰腺炎患者的值之间的重叠很大。另一方面，仅在胰腺癌患者中，胰液中ST-439的浓度显著较高。这些结果表明，在胰液中ST-439的测量作为肿瘤标志物比CA 19-9的测量更有用，而且，在胰液中CA 19-9的测定可用作非特异性胰腺损伤的敏感标志物。
Many of the recently developed tumor antigens detected by monoclonal antibodies are sugar chains and frequently associated with blood group substance. By immunohistological studies, we evaluated mainly the clinical usefulness and significance of the serum assay of CA-50 classified as a type 1 sugar chain, sialyl SSEA-1 classified as a type 2 sugar chain, and ST-439 with an undetermined structure, as well as their clinicopathological significance. In addition, the value of measurement of CA 19-9 and ST-439 in pancreatic juice was studied. The incidence of serum CA-50 was highest in pancreatic cancer (86%) and biliary tract cancer (66%), but relatively low in benign diseases. Moreover, the positivity and specificity of CA-50 as a tumor marker were no less useful than those of CA 19-9. However, comparison of serum levels of CA-50 with those of CA 19-9 in the same samples revealed a highly positive correlation in malignant diseases. Thus, improvement of the diagnostic rate through a combination assay of CA-50 and CA 19-9 seems unlikely. Both serodiagnostic and immunohistological studies showed that sialyl SSEA-1 and ST-439 were highly specific for tumor, whereas their appearances in serum or tumor were lower than CA 19-9 or CA-50 carrying the type 1 sugar chain. In addition, an appreciable number of sialyl SSEA-1 or ST-439 positive patients were found among those negative for CA 19-9 or CA-50. These results indicate that assay of sialyl SSEA-1 or ST-439 improves the diagnostic rate in combination with CA 19-9 or CA-50. Although the concentration of CA 19-9 in pancreatic juice from pancreatic cancer patients was highest, it was also significantly higher in patients with chronic pancreatitis than in controls. Furthermore, the overlap between the values in patients with cancer and those with chronic pancreatitis was great. On the other hand, the concentration of ST-439 in pancreatic juice was significantly higher only in patients with pancreatic cancer. These results indicate that the measurement of ST-439 in pancreatic juice is more useful as a tumor marker than measurement of CA 19-9, and that moreover, the assay of CA 19-9 in pancreatic juice could be used as a sensitive marker for nonspecific pancreatic injury.