Fibrous CaF2:Yb,Er@Sio(2)-PAA 'tumor patch' with NIR-triggered and trackable DOX release
Fibrous CaF2:Yb,Er@Sio(2)-PAA 'tumor patch' with NIR-triggered and trackable DOX release
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纤维状 CaF2:Yb,Er@Sio(2)-PAA“肿瘤贴片”，具有近红外触发且可追踪的 DOX 释放
DOI：
10.1016/j.matdes.2017.01.022
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发表时间：
2017
影响因子：
8.4
通讯作者：
Han Gaorong
中科院分区：
文献类型：
--
作者：
Xia Zhen;Fu Yike;Gu Tongxu;Li Yangyang;Liu Heng;Ren Zhaohui;Li Xiang;Han Gaorong
具有刺激响应特性的智能局部药物传递系统（ldds）为个性化癌症化疗提供了巨大的机会。在我们的工作中，设计并合成了一种可植入的“肿瘤贴片”，由上转换（UC）光致发光CaF2:Yb，Er纳米颗粒嵌入二氧化硅纳米纤维（CaF2:Yb,Er@SiO2）组成，用于阿霉素（DOX）的递送。在聚丙烯酸（PAA）功能化的辅助下，纤维网的DOX承载能力得到了显著提高。PAA修饰的CaF2:Yb，Er@SiO2nanofibers对DOX释放动力学表现出高度对应的光学响应。酸性条件下药物释放加速，其绿红光谱强度比（I550/I660）增加更快，反之亦然。更重要的是，在近红外（808 nm）激光照射下，DOX的释放动力学增强，从而增强了其体外抗癌效果。因此，这项研究为肿瘤化疗的个性化方案提供了另一种新的nir触发和监测DOX递送的植入式LDDS。
Smart localized drug delivery systems (LDDSs), with stimuli-responsive properties, offer tremendous opportunity for personalized cancer chemotherapy. In our work, an implantable ‘tumor patch’, consisting of upconversion (UC) photoluminescent CaF2:Yb,Er nanoparticles embedded within silica nanofibers (CaF2:Yb,Er@SiO2), was designed and synthesized for doxorubicin (DOX) delivery. DOX loading capacity of the fiber mesh was remarkably enhanced with assist of polyacrylic acid (PAA) functionalization. PAA modified CaF2:Yb,Er@SiO2nanofibers presented highly corresponding optical response to DOX release kinetics. Accelerated drug release in acidic condition induced more rapid increase in the spectral intensity ratio of green to red emission (I550/I660), andvice versa. More importantly, under the irradiation of NIR (808 nm) laser, DOX release kinetics and consequently thein-vitroanti-cancer efficacy were enhanced. This study has thus offered another new implantable LDDS with NIR-triggered and monitored DOX delivery for personalized protocols in tumor chemotherapy.