THE ANTIMALARIAL ACTION ON PLASMODIUM-FALCIPARUM OF QINGHAOSU AND ARTESUNATE IN COMBINATION WITH AGENTS WHICH MODULATE OXIDANT STRESS
THE ANTIMALARIAL ACTION ON PLASMODIUM-FALCIPARUM OF QINGHAOSU AND ARTESUNATE IN COMBINATION WITH AGENTS WHICH MODULATE OXIDANT STRESS
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DOI：
10.1016/0035-9203(87)90003-4
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发表时间：
1987-01-01
影响因子：
2.2
通讯作者：
YUTHAVONG, Y
中科院分区：
文献类型：
--
作者：
KRUNGKRAI, SR;YUTHAVONG, Y
青蒿素对恶性疟原虫培养物的抗疟活性随着氧张力的增加而增强。青蒿素衍生物青蒿琥酯与咪康唑和阿霉素具有协同作用，两者均通过增加氧化应激来发挥其化疗作用。过氧化氢酶、二硫苏糖醇和α-生育酚则降低了青好素的体外药效。这些结果表明，青蒿素和青蒿琥酯的作用可能与增加感染红细胞的氧化应激有关。
The antimalarial activity of qinghaosu (artemisinine) againstPlasmodium falciparumin culture was enhanced by increased oxygen tension. Artesunate, a qinghaosu derivative, showed synergistic effects with miconazole, and with doxorubicin, both of which have been suggested to exert their chemotherapeutic effect through increasing the oxidant stress. In contrast, catalase, dithiothreitol and α-tocopherol reduced the effectiveness of qinghaosuin vitro. These results suggest that the action of qinghaosu and artesunate might involve increase in oxidant stress on the infected red cells.